Decacationic Pillar[5]arene: A New Scaffold for the Development of (129)Xe MRI Imaging Agents

[Image: see text] A decacationic water-soluble pillar[5]arene possessing a nonsolvated hydrophobic core has been designed and synthesized. This supramolecular host is capable of binding xenon, as evidenced by hyperCEST depletion experiments. Fluorescence-based studies also demonstrate that xenon bin...

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Autores principales: Fernando, P. U. Ashvin I., Shepelytskyi, Yurii, Cesana, Paul T., Wade, Alanna, Grynko, Vira, Mendieta, Adriana M., Seveney, Lauren E., Brown, Joseph D., Hane, Francis T., Albert, Mitchell S., DeBoef, Brenton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643082/
https://www.ncbi.nlm.nih.gov/pubmed/33163761
http://dx.doi.org/10.1021/acsomega.0c02565
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author Fernando, P. U. Ashvin I.
Shepelytskyi, Yurii
Cesana, Paul T.
Wade, Alanna
Grynko, Vira
Mendieta, Adriana M.
Seveney, Lauren E.
Brown, Joseph D.
Hane, Francis T.
Albert, Mitchell S.
DeBoef, Brenton
author_facet Fernando, P. U. Ashvin I.
Shepelytskyi, Yurii
Cesana, Paul T.
Wade, Alanna
Grynko, Vira
Mendieta, Adriana M.
Seveney, Lauren E.
Brown, Joseph D.
Hane, Francis T.
Albert, Mitchell S.
DeBoef, Brenton
author_sort Fernando, P. U. Ashvin I.
collection PubMed
description [Image: see text] A decacationic water-soluble pillar[5]arene possessing a nonsolvated hydrophobic core has been designed and synthesized. This supramolecular host is capable of binding xenon, as evidenced by hyperCEST depletion experiments. Fluorescence-based studies also demonstrate that xenon binds into the cavity of the pillararene with an association constant of 4.6 × 10(3) M(–1). These data indicate that the water-soluble pillararene is a potential scaffold for building contrast agents that can be detected by xenon-129 magnetic resonance imaging.
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spelling pubmed-76430822020-11-06 Decacationic Pillar[5]arene: A New Scaffold for the Development of (129)Xe MRI Imaging Agents Fernando, P. U. Ashvin I. Shepelytskyi, Yurii Cesana, Paul T. Wade, Alanna Grynko, Vira Mendieta, Adriana M. Seveney, Lauren E. Brown, Joseph D. Hane, Francis T. Albert, Mitchell S. DeBoef, Brenton ACS Omega [Image: see text] A decacationic water-soluble pillar[5]arene possessing a nonsolvated hydrophobic core has been designed and synthesized. This supramolecular host is capable of binding xenon, as evidenced by hyperCEST depletion experiments. Fluorescence-based studies also demonstrate that xenon binds into the cavity of the pillararene with an association constant of 4.6 × 10(3) M(–1). These data indicate that the water-soluble pillararene is a potential scaffold for building contrast agents that can be detected by xenon-129 magnetic resonance imaging. American Chemical Society 2020-10-20 /pmc/articles/PMC7643082/ /pubmed/33163761 http://dx.doi.org/10.1021/acsomega.0c02565 Text en © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Fernando, P. U. Ashvin I.
Shepelytskyi, Yurii
Cesana, Paul T.
Wade, Alanna
Grynko, Vira
Mendieta, Adriana M.
Seveney, Lauren E.
Brown, Joseph D.
Hane, Francis T.
Albert, Mitchell S.
DeBoef, Brenton
Decacationic Pillar[5]arene: A New Scaffold for the Development of (129)Xe MRI Imaging Agents
title Decacationic Pillar[5]arene: A New Scaffold for the Development of (129)Xe MRI Imaging Agents
title_full Decacationic Pillar[5]arene: A New Scaffold for the Development of (129)Xe MRI Imaging Agents
title_fullStr Decacationic Pillar[5]arene: A New Scaffold for the Development of (129)Xe MRI Imaging Agents
title_full_unstemmed Decacationic Pillar[5]arene: A New Scaffold for the Development of (129)Xe MRI Imaging Agents
title_short Decacationic Pillar[5]arene: A New Scaffold for the Development of (129)Xe MRI Imaging Agents
title_sort decacationic pillar[5]arene: a new scaffold for the development of (129)xe mri imaging agents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643082/
https://www.ncbi.nlm.nih.gov/pubmed/33163761
http://dx.doi.org/10.1021/acsomega.0c02565
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