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Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson’s disease over five years follow-up
Constipation and REM sleep behaviour disorder (RBD) are the earliest non-motor manifestations of Parkinson’s disease (PD). Among non-motor symptoms of PD, it is unclear whether constipation and RBD at early stages of PD are related to cognitive outcomes at later stages. Herein, this study aims to in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643116/ https://www.ncbi.nlm.nih.gov/pubmed/33149217 http://dx.doi.org/10.1038/s41598-020-75800-4 |
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author | Kong, Wee Lee Huang, Yue Qian, Elizabeth Morris, Margaret J. |
author_facet | Kong, Wee Lee Huang, Yue Qian, Elizabeth Morris, Margaret J. |
author_sort | Kong, Wee Lee |
collection | PubMed |
description | Constipation and REM sleep behaviour disorder (RBD) are the earliest non-motor manifestations of Parkinson’s disease (PD). Among non-motor symptoms of PD, it is unclear whether constipation and RBD at early stages of PD are related to cognitive outcomes at later stages. Herein, this study aims to investigate whether the presence of constipation and RBD have an impact on future cognitive outcomes in PD. Access to Parkinson’s Progression Markers Initiative (PPMI) database of 360 PD patients with longitudinal observation was requested. Constipation, probable RBD (pRBD) and neuropsychological task scores of PD patients were assessed at baseline and after 5 years. Linear mixed-effects modelling, controlling for gender, age, years of education and LEDD was used to evaluate the association between baseline constipation, pRBD and cognitive performance on follow-up. Gender differences in neuropsychological test performances were found, with men having worse global cognition, speed-attention processing, verbal learning and memory than women at early stages of the disease. We found constipation and pRBD are strongly associated with future decline in some cognitive measures among PD patients, more prominently in men. Our data suggest that early assessment of pRBD and constipation may allow better understanding of the progression of cognitive changes in later phases of PD. |
format | Online Article Text |
id | pubmed-7643116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76431162020-11-06 Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson’s disease over five years follow-up Kong, Wee Lee Huang, Yue Qian, Elizabeth Morris, Margaret J. Sci Rep Article Constipation and REM sleep behaviour disorder (RBD) are the earliest non-motor manifestations of Parkinson’s disease (PD). Among non-motor symptoms of PD, it is unclear whether constipation and RBD at early stages of PD are related to cognitive outcomes at later stages. Herein, this study aims to investigate whether the presence of constipation and RBD have an impact on future cognitive outcomes in PD. Access to Parkinson’s Progression Markers Initiative (PPMI) database of 360 PD patients with longitudinal observation was requested. Constipation, probable RBD (pRBD) and neuropsychological task scores of PD patients were assessed at baseline and after 5 years. Linear mixed-effects modelling, controlling for gender, age, years of education and LEDD was used to evaluate the association between baseline constipation, pRBD and cognitive performance on follow-up. Gender differences in neuropsychological test performances were found, with men having worse global cognition, speed-attention processing, verbal learning and memory than women at early stages of the disease. We found constipation and pRBD are strongly associated with future decline in some cognitive measures among PD patients, more prominently in men. Our data suggest that early assessment of pRBD and constipation may allow better understanding of the progression of cognitive changes in later phases of PD. Nature Publishing Group UK 2020-11-04 /pmc/articles/PMC7643116/ /pubmed/33149217 http://dx.doi.org/10.1038/s41598-020-75800-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kong, Wee Lee Huang, Yue Qian, Elizabeth Morris, Margaret J. Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson’s disease over five years follow-up |
title | Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson’s disease over five years follow-up |
title_full | Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson’s disease over five years follow-up |
title_fullStr | Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson’s disease over five years follow-up |
title_full_unstemmed | Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson’s disease over five years follow-up |
title_short | Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson’s disease over five years follow-up |
title_sort | constipation and sleep behaviour disorder associate with processing speed and attention in males with parkinson’s disease over five years follow-up |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643116/ https://www.ncbi.nlm.nih.gov/pubmed/33149217 http://dx.doi.org/10.1038/s41598-020-75800-4 |
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