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Pan-cancer landscape of homologous recombination deficiency

Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD) that can discriminate BRCA1- and BRCA2-subtype...

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Detalles Bibliográficos
Autores principales:	Nguyen, Luan, W. M. Martens, John, Van Hoeck, Arne, Cuppen, Edwin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643118/ https://www.ncbi.nlm.nih.gov/pubmed/33149131 http://dx.doi.org/10.1038/s41467-020-19406-4

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