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Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function

Airway inflammation and chronic lung infections in cystic fibrosis (CF) patients are mostly caused by bacteria, e.g. Pseudomonas aeruginosa (PA). The role of fungi in the CF lung is still not well elucidated, but evidence for a harmful and complex role is getting stronger. The most common filamentou...

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Autores principales: Düesberg, Uta, Wosniok, Julia, Naehrlich, Lutz, Eschenhagen, Patience, Schwarz, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643137/
https://www.ncbi.nlm.nih.gov/pubmed/33149181
http://dx.doi.org/10.1038/s41598-020-75886-w
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author Düesberg, Uta
Wosniok, Julia
Naehrlich, Lutz
Eschenhagen, Patience
Schwarz, Carsten
author_facet Düesberg, Uta
Wosniok, Julia
Naehrlich, Lutz
Eschenhagen, Patience
Schwarz, Carsten
author_sort Düesberg, Uta
collection PubMed
description Airway inflammation and chronic lung infections in cystic fibrosis (CF) patients are mostly caused by bacteria, e.g. Pseudomonas aeruginosa (PA). The role of fungi in the CF lung is still not well elucidated, but evidence for a harmful and complex role is getting stronger. The most common filamentous fungus in CF is Aspergillus fumigatus (AF). Age and continuous antibiotic treatment have been discussed as risk factors for AF colonisation but did not differentiate between transient and persistent AF colonisation. Also, the impact of co-colonisation of PA and AF on lung function is still under investigation. Data from patients with CF registered in the German Cystic Fibrosis Registry database in 2016 and 2017 were retrospectively analysed, involving descriptive and multivariate analysis to assess risk factors for transient or persistent AF colonisation. Age represented an independent risk factor for persistent AF colonisation. Prevalence was low in children less than ten years, highest in the middle age and getting lower in higher age (≥ 50 years). Continuous antibiotic lung treatment was significantly associated with AF prevalence in all age groups. CF patients with chronic PA infection had a lower lung function (FEV1%predicted), which was not influenced by an additional AF colonisation. AF colonisation without chronic PA infection, however, was significantly associated with a lower function, too. Older age up to 49 years and continuous antibiotic use were found to be the main risk factors for AF permanent colonisation. AF might be associated with decrease of lung function if not disguised by chronic PA infection.
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spelling pubmed-76431372020-11-06 Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function Düesberg, Uta Wosniok, Julia Naehrlich, Lutz Eschenhagen, Patience Schwarz, Carsten Sci Rep Article Airway inflammation and chronic lung infections in cystic fibrosis (CF) patients are mostly caused by bacteria, e.g. Pseudomonas aeruginosa (PA). The role of fungi in the CF lung is still not well elucidated, but evidence for a harmful and complex role is getting stronger. The most common filamentous fungus in CF is Aspergillus fumigatus (AF). Age and continuous antibiotic treatment have been discussed as risk factors for AF colonisation but did not differentiate between transient and persistent AF colonisation. Also, the impact of co-colonisation of PA and AF on lung function is still under investigation. Data from patients with CF registered in the German Cystic Fibrosis Registry database in 2016 and 2017 were retrospectively analysed, involving descriptive and multivariate analysis to assess risk factors for transient or persistent AF colonisation. Age represented an independent risk factor for persistent AF colonisation. Prevalence was low in children less than ten years, highest in the middle age and getting lower in higher age (≥ 50 years). Continuous antibiotic lung treatment was significantly associated with AF prevalence in all age groups. CF patients with chronic PA infection had a lower lung function (FEV1%predicted), which was not influenced by an additional AF colonisation. AF colonisation without chronic PA infection, however, was significantly associated with a lower function, too. Older age up to 49 years and continuous antibiotic use were found to be the main risk factors for AF permanent colonisation. AF might be associated with decrease of lung function if not disguised by chronic PA infection. Nature Publishing Group UK 2020-11-04 /pmc/articles/PMC7643137/ /pubmed/33149181 http://dx.doi.org/10.1038/s41598-020-75886-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Düesberg, Uta
Wosniok, Julia
Naehrlich, Lutz
Eschenhagen, Patience
Schwarz, Carsten
Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function
title Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function
title_full Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function
title_fullStr Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function
title_full_unstemmed Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function
title_short Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function
title_sort risk factors for respiratory aspergillus fumigatus in german cystic fibrosis patients and impact on lung function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643137/
https://www.ncbi.nlm.nih.gov/pubmed/33149181
http://dx.doi.org/10.1038/s41598-020-75886-w
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