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Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption
Carbohydrate malabsorption and subsequent gastrointestinal symptoms are a common clinical problem in pediatrics. Hydrogen (H(2)) and methane (CH(4)) breath tests are a cheap and non-invasive procedure for diagnosing fructose and lactose malabsorption (FM/LM) but test accuracy and reliability as well...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643139/ https://www.ncbi.nlm.nih.gov/pubmed/33149229 http://dx.doi.org/10.1038/s41598-020-75987-6 |
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author | Schneider, Christof Wutzke, Klaus D. Däbritz, Jan |
author_facet | Schneider, Christof Wutzke, Klaus D. Däbritz, Jan |
author_sort | Schneider, Christof |
collection | PubMed |
description | Carbohydrate malabsorption and subsequent gastrointestinal symptoms are a common clinical problem in pediatrics. Hydrogen (H(2)) and methane (CH(4)) breath tests are a cheap and non-invasive procedure for diagnosing fructose and lactose malabsorption (FM/LM) but test accuracy and reliability as well as the impact of non-hydrogen producers (NHP) is unclear. CH(4) breath tests (MBT), blood sugar tests (BST) and clinical symptoms were compared with H(2) breath tests (HBT) for FM/LM. 187/82 tests were performed in children (2 to 18 years) with unclear chronic/recurrent abdominal pain and suspected FM/LM. In FM and LM, we found a significant correlation between HBT and MBT/BST. In LM, MBT differentiated most of the patients correctly and BST might be used as an exclusion test. However, additional MBT and BST had no diagnostic advantage in FM. NHP still remain a group of patients, which cannot be identified using the recommended CH(4) cut-off values in FM or LM. Reported symptoms during breath tests are not a reliable method to diagnose FM/LM. Overall a combined test approach might help in diagnosing children with suspected carbohydrate malabsorption. |
format | Online Article Text |
id | pubmed-7643139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76431392020-11-06 Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption Schneider, Christof Wutzke, Klaus D. Däbritz, Jan Sci Rep Article Carbohydrate malabsorption and subsequent gastrointestinal symptoms are a common clinical problem in pediatrics. Hydrogen (H(2)) and methane (CH(4)) breath tests are a cheap and non-invasive procedure for diagnosing fructose and lactose malabsorption (FM/LM) but test accuracy and reliability as well as the impact of non-hydrogen producers (NHP) is unclear. CH(4) breath tests (MBT), blood sugar tests (BST) and clinical symptoms were compared with H(2) breath tests (HBT) for FM/LM. 187/82 tests were performed in children (2 to 18 years) with unclear chronic/recurrent abdominal pain and suspected FM/LM. In FM and LM, we found a significant correlation between HBT and MBT/BST. In LM, MBT differentiated most of the patients correctly and BST might be used as an exclusion test. However, additional MBT and BST had no diagnostic advantage in FM. NHP still remain a group of patients, which cannot be identified using the recommended CH(4) cut-off values in FM or LM. Reported symptoms during breath tests are not a reliable method to diagnose FM/LM. Overall a combined test approach might help in diagnosing children with suspected carbohydrate malabsorption. Nature Publishing Group UK 2020-11-04 /pmc/articles/PMC7643139/ /pubmed/33149229 http://dx.doi.org/10.1038/s41598-020-75987-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Schneider, Christof Wutzke, Klaus D. Däbritz, Jan Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption |
title | Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption |
title_full | Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption |
title_fullStr | Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption |
title_full_unstemmed | Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption |
title_short | Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption |
title_sort | methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643139/ https://www.ncbi.nlm.nih.gov/pubmed/33149229 http://dx.doi.org/10.1038/s41598-020-75987-6 |
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