Apatinib as an alternative therapy for advanced hepatocellular carcinoma

Angiogenesis plays an important role in the occurrence and development of tumors. Registered tyrosine kinase inhibitors targeting vascular endothelial growth factor reduce angiogenesis. Apatinib, a tyrosine kinase inhibitor, can specifically inhibit vascular endothelial growth factor receptor 2, sho...

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Detalles Bibliográficos
Autores principales: Zhang, Xi-Hao, Cao, Man-Qing, Li, Xiu-Xiu, Zhang, Ti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643208/
https://www.ncbi.nlm.nih.gov/pubmed/33200015
http://dx.doi.org/10.4254/wjh.v12.i10.766
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author Zhang, Xi-Hao
Cao, Man-Qing
Li, Xiu-Xiu
Zhang, Ti
author_facet Zhang, Xi-Hao
Cao, Man-Qing
Li, Xiu-Xiu
Zhang, Ti
author_sort Zhang, Xi-Hao
collection PubMed
description Angiogenesis plays an important role in the occurrence and development of tumors. Registered tyrosine kinase inhibitors targeting vascular endothelial growth factor reduce angiogenesis. Apatinib, a tyrosine kinase inhibitor, can specifically inhibit vascular endothelial growth factor receptor 2, showing encouraging anti-tumor effects in a variety of tumors including advanced hepatocellular carcinoma (HCC). This article intends to review the clinical research and application prospects of apatinib in the field of HCC.
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spelling pubmed-76432082020-11-15 Apatinib as an alternative therapy for advanced hepatocellular carcinoma Zhang, Xi-Hao Cao, Man-Qing Li, Xiu-Xiu Zhang, Ti World J Hepatol Minireviews Angiogenesis plays an important role in the occurrence and development of tumors. Registered tyrosine kinase inhibitors targeting vascular endothelial growth factor reduce angiogenesis. Apatinib, a tyrosine kinase inhibitor, can specifically inhibit vascular endothelial growth factor receptor 2, showing encouraging anti-tumor effects in a variety of tumors including advanced hepatocellular carcinoma (HCC). This article intends to review the clinical research and application prospects of apatinib in the field of HCC. Baishideng Publishing Group Inc 2020-10-27 2020-10-27 /pmc/articles/PMC7643208/ /pubmed/33200015 http://dx.doi.org/10.4254/wjh.v12.i10.766 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Zhang, Xi-Hao
Cao, Man-Qing
Li, Xiu-Xiu
Zhang, Ti
Apatinib as an alternative therapy for advanced hepatocellular carcinoma
title Apatinib as an alternative therapy for advanced hepatocellular carcinoma
title_full Apatinib as an alternative therapy for advanced hepatocellular carcinoma
title_fullStr Apatinib as an alternative therapy for advanced hepatocellular carcinoma
title_full_unstemmed Apatinib as an alternative therapy for advanced hepatocellular carcinoma
title_short Apatinib as an alternative therapy for advanced hepatocellular carcinoma
title_sort apatinib as an alternative therapy for advanced hepatocellular carcinoma
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643208/
https://www.ncbi.nlm.nih.gov/pubmed/33200015
http://dx.doi.org/10.4254/wjh.v12.i10.766
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AT lixiuxiu apatinibasanalternativetherapyforadvancedhepatocellularcarcinoma
AT zhangti apatinibasanalternativetherapyforadvancedhepatocellularcarcinoma

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