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Whole‐brain functional connectivity correlates of obesity phenotypes
Dysregulated neural mechanisms in reward and somatosensory circuits result in an increased appetitive drive for and reduced inhibitory control of eating, which in turn causes obesity. Despite many studies investigating the brain mechanisms of obesity, the role of macroscale whole‐brain functional co...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643372/ https://www.ncbi.nlm.nih.gov/pubmed/32804441 http://dx.doi.org/10.1002/hbm.25167 |
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author | Park, Bo‐yong Byeon, Kyoungseob Lee, Mi Ji Chung, Chin‐Sang Kim, Se‐Hong Morys, Filip Bernhardt, Boris Dagher, Alain Park, Hyunjin |
author_facet | Park, Bo‐yong Byeon, Kyoungseob Lee, Mi Ji Chung, Chin‐Sang Kim, Se‐Hong Morys, Filip Bernhardt, Boris Dagher, Alain Park, Hyunjin |
author_sort | Park, Bo‐yong |
collection | PubMed |
description | Dysregulated neural mechanisms in reward and somatosensory circuits result in an increased appetitive drive for and reduced inhibitory control of eating, which in turn causes obesity. Despite many studies investigating the brain mechanisms of obesity, the role of macroscale whole‐brain functional connectivity remains poorly understood. Here, we identified a neuroimaging‐based functional connectivity pattern associated with obesity phenotypes by using functional connectivity analysis combined with machine learning in a large‐scale (n ~ 2,400) dataset spanning four independent cohorts. We found that brain regions containing the reward circuit positively associated with obesity phenotypes, while brain regions for sensory processing showed negative associations. Our study introduces a novel perspective for understanding how the whole‐brain functional connectivity correlates with obesity phenotypes. Furthermore, we demonstrated the generalizability of our findings by correlating the functional connectivity pattern with obesity phenotypes in three independent datasets containing subjects of multiple ages and ethnicities. Our findings suggest that obesity phenotypes can be understood in terms of macroscale whole‐brain functional connectivity and have important implications for the obesity neuroimaging community. |
format | Online Article Text |
id | pubmed-7643372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76433722020-11-13 Whole‐brain functional connectivity correlates of obesity phenotypes Park, Bo‐yong Byeon, Kyoungseob Lee, Mi Ji Chung, Chin‐Sang Kim, Se‐Hong Morys, Filip Bernhardt, Boris Dagher, Alain Park, Hyunjin Hum Brain Mapp Research Articles Dysregulated neural mechanisms in reward and somatosensory circuits result in an increased appetitive drive for and reduced inhibitory control of eating, which in turn causes obesity. Despite many studies investigating the brain mechanisms of obesity, the role of macroscale whole‐brain functional connectivity remains poorly understood. Here, we identified a neuroimaging‐based functional connectivity pattern associated with obesity phenotypes by using functional connectivity analysis combined with machine learning in a large‐scale (n ~ 2,400) dataset spanning four independent cohorts. We found that brain regions containing the reward circuit positively associated with obesity phenotypes, while brain regions for sensory processing showed negative associations. Our study introduces a novel perspective for understanding how the whole‐brain functional connectivity correlates with obesity phenotypes. Furthermore, we demonstrated the generalizability of our findings by correlating the functional connectivity pattern with obesity phenotypes in three independent datasets containing subjects of multiple ages and ethnicities. Our findings suggest that obesity phenotypes can be understood in terms of macroscale whole‐brain functional connectivity and have important implications for the obesity neuroimaging community. John Wiley & Sons, Inc. 2020-08-17 /pmc/articles/PMC7643372/ /pubmed/32804441 http://dx.doi.org/10.1002/hbm.25167 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Park, Bo‐yong Byeon, Kyoungseob Lee, Mi Ji Chung, Chin‐Sang Kim, Se‐Hong Morys, Filip Bernhardt, Boris Dagher, Alain Park, Hyunjin Whole‐brain functional connectivity correlates of obesity phenotypes |
title | Whole‐brain functional connectivity correlates of obesity phenotypes |
title_full | Whole‐brain functional connectivity correlates of obesity phenotypes |
title_fullStr | Whole‐brain functional connectivity correlates of obesity phenotypes |
title_full_unstemmed | Whole‐brain functional connectivity correlates of obesity phenotypes |
title_short | Whole‐brain functional connectivity correlates of obesity phenotypes |
title_sort | whole‐brain functional connectivity correlates of obesity phenotypes |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643372/ https://www.ncbi.nlm.nih.gov/pubmed/32804441 http://dx.doi.org/10.1002/hbm.25167 |
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