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Whole‐brain functional connectivity correlates of obesity phenotypes

Dysregulated neural mechanisms in reward and somatosensory circuits result in an increased appetitive drive for and reduced inhibitory control of eating, which in turn causes obesity. Despite many studies investigating the brain mechanisms of obesity, the role of macroscale whole‐brain functional co...

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Autores principales: Park, Bo‐yong, Byeon, Kyoungseob, Lee, Mi Ji, Chung, Chin‐Sang, Kim, Se‐Hong, Morys, Filip, Bernhardt, Boris, Dagher, Alain, Park, Hyunjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643372/
https://www.ncbi.nlm.nih.gov/pubmed/32804441
http://dx.doi.org/10.1002/hbm.25167
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author Park, Bo‐yong
Byeon, Kyoungseob
Lee, Mi Ji
Chung, Chin‐Sang
Kim, Se‐Hong
Morys, Filip
Bernhardt, Boris
Dagher, Alain
Park, Hyunjin
author_facet Park, Bo‐yong
Byeon, Kyoungseob
Lee, Mi Ji
Chung, Chin‐Sang
Kim, Se‐Hong
Morys, Filip
Bernhardt, Boris
Dagher, Alain
Park, Hyunjin
author_sort Park, Bo‐yong
collection PubMed
description Dysregulated neural mechanisms in reward and somatosensory circuits result in an increased appetitive drive for and reduced inhibitory control of eating, which in turn causes obesity. Despite many studies investigating the brain mechanisms of obesity, the role of macroscale whole‐brain functional connectivity remains poorly understood. Here, we identified a neuroimaging‐based functional connectivity pattern associated with obesity phenotypes by using functional connectivity analysis combined with machine learning in a large‐scale (n ~ 2,400) dataset spanning four independent cohorts. We found that brain regions containing the reward circuit positively associated with obesity phenotypes, while brain regions for sensory processing showed negative associations. Our study introduces a novel perspective for understanding how the whole‐brain functional connectivity correlates with obesity phenotypes. Furthermore, we demonstrated the generalizability of our findings by correlating the functional connectivity pattern with obesity phenotypes in three independent datasets containing subjects of multiple ages and ethnicities. Our findings suggest that obesity phenotypes can be understood in terms of macroscale whole‐brain functional connectivity and have important implications for the obesity neuroimaging community.
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spelling pubmed-76433722020-11-13 Whole‐brain functional connectivity correlates of obesity phenotypes Park, Bo‐yong Byeon, Kyoungseob Lee, Mi Ji Chung, Chin‐Sang Kim, Se‐Hong Morys, Filip Bernhardt, Boris Dagher, Alain Park, Hyunjin Hum Brain Mapp Research Articles Dysregulated neural mechanisms in reward and somatosensory circuits result in an increased appetitive drive for and reduced inhibitory control of eating, which in turn causes obesity. Despite many studies investigating the brain mechanisms of obesity, the role of macroscale whole‐brain functional connectivity remains poorly understood. Here, we identified a neuroimaging‐based functional connectivity pattern associated with obesity phenotypes by using functional connectivity analysis combined with machine learning in a large‐scale (n ~ 2,400) dataset spanning four independent cohorts. We found that brain regions containing the reward circuit positively associated with obesity phenotypes, while brain regions for sensory processing showed negative associations. Our study introduces a novel perspective for understanding how the whole‐brain functional connectivity correlates with obesity phenotypes. Furthermore, we demonstrated the generalizability of our findings by correlating the functional connectivity pattern with obesity phenotypes in three independent datasets containing subjects of multiple ages and ethnicities. Our findings suggest that obesity phenotypes can be understood in terms of macroscale whole‐brain functional connectivity and have important implications for the obesity neuroimaging community. John Wiley & Sons, Inc. 2020-08-17 /pmc/articles/PMC7643372/ /pubmed/32804441 http://dx.doi.org/10.1002/hbm.25167 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Park, Bo‐yong
Byeon, Kyoungseob
Lee, Mi Ji
Chung, Chin‐Sang
Kim, Se‐Hong
Morys, Filip
Bernhardt, Boris
Dagher, Alain
Park, Hyunjin
Whole‐brain functional connectivity correlates of obesity phenotypes
title Whole‐brain functional connectivity correlates of obesity phenotypes
title_full Whole‐brain functional connectivity correlates of obesity phenotypes
title_fullStr Whole‐brain functional connectivity correlates of obesity phenotypes
title_full_unstemmed Whole‐brain functional connectivity correlates of obesity phenotypes
title_short Whole‐brain functional connectivity correlates of obesity phenotypes
title_sort whole‐brain functional connectivity correlates of obesity phenotypes
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643372/
https://www.ncbi.nlm.nih.gov/pubmed/32804441
http://dx.doi.org/10.1002/hbm.25167
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