Targeting ferroptosis in breast cancer

Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status...

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Autores principales: Li, Zhaoqing, Chen, Lini, Chen, Cong, Zhou, Yulu, Hu, Dengdi, Yang, Jingjing, Chen, Yongxia, Zhuo, Wenying, Mao, Misha, Zhang, Xun, Xu, Ling, Wang, Linbo, Zhou, Jichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643412/
https://www.ncbi.nlm.nih.gov/pubmed/33292585
http://dx.doi.org/10.1186/s40364-020-00230-3
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author Li, Zhaoqing
Chen, Lini
Chen, Cong
Zhou, Yulu
Hu, Dengdi
Yang, Jingjing
Chen, Yongxia
Zhuo, Wenying
Mao, Misha
Zhang, Xun
Xu, Ling
Wang, Linbo
Zhou, Jichun
author_facet Li, Zhaoqing
Chen, Lini
Chen, Cong
Zhou, Yulu
Hu, Dengdi
Yang, Jingjing
Chen, Yongxia
Zhuo, Wenying
Mao, Misha
Zhang, Xun
Xu, Ling
Wang, Linbo
Zhou, Jichun
author_sort Li, Zhaoqing
collection PubMed
description Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to previous studies. We also compare ferroptosis to common regulated cell death patterns and discuss the sensitivity to ferroptosis in different subtypes of breast cancer. We propose that viewing ferroptosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.
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spelling pubmed-76434122020-11-06 Targeting ferroptosis in breast cancer Li, Zhaoqing Chen, Lini Chen, Cong Zhou, Yulu Hu, Dengdi Yang, Jingjing Chen, Yongxia Zhuo, Wenying Mao, Misha Zhang, Xun Xu, Ling Wang, Linbo Zhou, Jichun Biomark Res Review Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to previous studies. We also compare ferroptosis to common regulated cell death patterns and discuss the sensitivity to ferroptosis in different subtypes of breast cancer. We propose that viewing ferroptosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer. BioMed Central 2020-11-05 /pmc/articles/PMC7643412/ /pubmed/33292585 http://dx.doi.org/10.1186/s40364-020-00230-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Li, Zhaoqing
Chen, Lini
Chen, Cong
Zhou, Yulu
Hu, Dengdi
Yang, Jingjing
Chen, Yongxia
Zhuo, Wenying
Mao, Misha
Zhang, Xun
Xu, Ling
Wang, Linbo
Zhou, Jichun
Targeting ferroptosis in breast cancer
title Targeting ferroptosis in breast cancer
title_full Targeting ferroptosis in breast cancer
title_fullStr Targeting ferroptosis in breast cancer
title_full_unstemmed Targeting ferroptosis in breast cancer
title_short Targeting ferroptosis in breast cancer
title_sort targeting ferroptosis in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643412/
https://www.ncbi.nlm.nih.gov/pubmed/33292585
http://dx.doi.org/10.1186/s40364-020-00230-3
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