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Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes
BACKGROUND: Neutralising antibodies to sclerostin (Scl-Ab) have shown significant potential to induce bone formation and decrease bone resorption, increase strength and substantially reduce fracture risk in animal studies and clinical trials. Mechanical loading negatively regulates sclerostin expres...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643443/ https://www.ncbi.nlm.nih.gov/pubmed/33148174 http://dx.doi.org/10.1186/s12860-020-00322-w |