Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes

Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease characterized by elevated blood glucose. Multiple environmental and genetic factors can increase the risk of T2DM and its complications, and genetic polymorphisms are no exception. This review is mainly focused on the related g...

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Autores principales: Li, Cuilin, Yang, Yuping, Liu, Xin, Li, Zhongyu, Liu, Hong, Tan, Qiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643457/
https://www.ncbi.nlm.nih.gov/pubmed/33292424
http://dx.doi.org/10.1186/s13098-020-00604-5
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author Li, Cuilin
Yang, Yuping
Liu, Xin
Li, Zhongyu
Liu, Hong
Tan, Qiuhong
author_facet Li, Cuilin
Yang, Yuping
Liu, Xin
Li, Zhongyu
Liu, Hong
Tan, Qiuhong
author_sort Li, Cuilin
collection PubMed
description Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease characterized by elevated blood glucose. Multiple environmental and genetic factors can increase the risk of T2DM and its complications, and genetic polymorphisms are no exception. This review is mainly focused on the related genes involved in glucose metabolic, including G6PC2, GCK, GCKR and OCT3. In this review, we have summarized the results reported globally and found that the genetic variants of GCK and OCT3 genes is a risk factor for T2DM while G6PC2 and GCKR genes are controversial in different ethnic groups. Hopefully, this summary could possibly help researchers and physicians understand the mechanism of T2DM so as to diagnose and even prevent T2DM at early time.
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spelling pubmed-76434572020-11-06 Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes Li, Cuilin Yang, Yuping Liu, Xin Li, Zhongyu Liu, Hong Tan, Qiuhong Diabetol Metab Syndr Review Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease characterized by elevated blood glucose. Multiple environmental and genetic factors can increase the risk of T2DM and its complications, and genetic polymorphisms are no exception. This review is mainly focused on the related genes involved in glucose metabolic, including G6PC2, GCK, GCKR and OCT3. In this review, we have summarized the results reported globally and found that the genetic variants of GCK and OCT3 genes is a risk factor for T2DM while G6PC2 and GCKR genes are controversial in different ethnic groups. Hopefully, this summary could possibly help researchers and physicians understand the mechanism of T2DM so as to diagnose and even prevent T2DM at early time. BioMed Central 2020-11-04 /pmc/articles/PMC7643457/ /pubmed/33292424 http://dx.doi.org/10.1186/s13098-020-00604-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Li, Cuilin
Yang, Yuping
Liu, Xin
Li, Zhongyu
Liu, Hong
Tan, Qiuhong
Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes
title Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes
title_full Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes
title_fullStr Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes
title_full_unstemmed Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes
title_short Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes
title_sort glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643457/
https://www.ncbi.nlm.nih.gov/pubmed/33292424
http://dx.doi.org/10.1186/s13098-020-00604-5
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