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Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case–control study

INTRODUCTION: Exercise acutely alters markers of bone resorption and formation. As risk of fracture is increased in patients with type 1 diabetes, understanding if exercise-induced bone turnover is affected within this population is prudent. We assessed bone turnover responses to acute exercise in i...

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Autores principales: Taylor, Guy S, Moser, Othmar, Smith, Kieran, Shaw, Andy, Tang, Jonathan C Y, Fraser, William D, Eckstein, Max L, Aziz, Faisal, Stevenson, Emma J, Shaw, James A, West, Daniel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643495/
https://www.ncbi.nlm.nih.gov/pubmed/33148690
http://dx.doi.org/10.1136/bmjdrc-2020-001779
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author Taylor, Guy S
Moser, Othmar
Smith, Kieran
Shaw, Andy
Tang, Jonathan C Y
Fraser, William D
Eckstein, Max L
Aziz, Faisal
Stevenson, Emma J
Shaw, James A
West, Daniel J
author_facet Taylor, Guy S
Moser, Othmar
Smith, Kieran
Shaw, Andy
Tang, Jonathan C Y
Fraser, William D
Eckstein, Max L
Aziz, Faisal
Stevenson, Emma J
Shaw, James A
West, Daniel J
author_sort Taylor, Guy S
collection PubMed
description INTRODUCTION: Exercise acutely alters markers of bone resorption and formation. As risk of fracture is increased in patients with type 1 diabetes, understanding if exercise-induced bone turnover is affected within this population is prudent. We assessed bone turnover responses to acute exercise in individuals with long-duration type 1 diabetes and matched controls. RESEARCH DESIGN AND METHODS: Participants with type 1 diabetes (n=15; age: 38.7±13.3; glycosylated hemoglobin: 60.5±6.7 mmol/mol; diabetes duration: 19.3±11.4 years) and age-matched, fitness-matched, and body mass index-matched controls (n=15) completed 45 min of incline walking (60% peak oxygen uptake). Blood samples were collected at baseline and immediately, 30 min, and 60 min postexercise. Markers of bone resorption (β-C-terminal cross-linked telopeptide of type 1 collagen, β-CTx) and formation (procollagen type-1 amino-terminal propeptide, P1NP), parathyroid hormone (PTH), phosphate, and calcium (albumin-adjusted and ionized) were measured. Data (mean±SD) were analyzed by a mixed-model analysis of variance. RESULTS: Baseline concentrations of P1NP and β-CTx were comparable between participants with type 1 diabetes and controls. P1NP did not change with exercise (p=0.20) but β-CTx decreased (p<0.001) in both groups, but less so in participants with type 1 diabetes compared with controls (−9.2±3.7%; p=0.02). PTH and phosphate increased immediately postexercise in both groups; only PTH was raised at 30 min postexercise (p<0.001), with no between-group differences (p>0.39). Participants with type 1 diabetes had reduced albumin and ionized calcium at all sample points (p<0.01). CONCLUSIONS: Following exercise, participants with type 1 diabetes displayed similar time-course changes in markers of bone formation and associated metabolites, but an attenuated suppression in bone resorption. The reduced albumin and ionized calcium may have implications for future bone health. Further investigation of the interactions between type 1 diabetes, differing modalities and intensities of exercise, and bone health is warranted.
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spelling pubmed-76434952020-11-12 Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case–control study Taylor, Guy S Moser, Othmar Smith, Kieran Shaw, Andy Tang, Jonathan C Y Fraser, William D Eckstein, Max L Aziz, Faisal Stevenson, Emma J Shaw, James A West, Daniel J BMJ Open Diabetes Res Care Pathophysiology/Complications INTRODUCTION: Exercise acutely alters markers of bone resorption and formation. As risk of fracture is increased in patients with type 1 diabetes, understanding if exercise-induced bone turnover is affected within this population is prudent. We assessed bone turnover responses to acute exercise in individuals with long-duration type 1 diabetes and matched controls. RESEARCH DESIGN AND METHODS: Participants with type 1 diabetes (n=15; age: 38.7±13.3; glycosylated hemoglobin: 60.5±6.7 mmol/mol; diabetes duration: 19.3±11.4 years) and age-matched, fitness-matched, and body mass index-matched controls (n=15) completed 45 min of incline walking (60% peak oxygen uptake). Blood samples were collected at baseline and immediately, 30 min, and 60 min postexercise. Markers of bone resorption (β-C-terminal cross-linked telopeptide of type 1 collagen, β-CTx) and formation (procollagen type-1 amino-terminal propeptide, P1NP), parathyroid hormone (PTH), phosphate, and calcium (albumin-adjusted and ionized) were measured. Data (mean±SD) were analyzed by a mixed-model analysis of variance. RESULTS: Baseline concentrations of P1NP and β-CTx were comparable between participants with type 1 diabetes and controls. P1NP did not change with exercise (p=0.20) but β-CTx decreased (p<0.001) in both groups, but less so in participants with type 1 diabetes compared with controls (−9.2±3.7%; p=0.02). PTH and phosphate increased immediately postexercise in both groups; only PTH was raised at 30 min postexercise (p<0.001), with no between-group differences (p>0.39). Participants with type 1 diabetes had reduced albumin and ionized calcium at all sample points (p<0.01). CONCLUSIONS: Following exercise, participants with type 1 diabetes displayed similar time-course changes in markers of bone formation and associated metabolites, but an attenuated suppression in bone resorption. The reduced albumin and ionized calcium may have implications for future bone health. Further investigation of the interactions between type 1 diabetes, differing modalities and intensities of exercise, and bone health is warranted. BMJ Publishing Group 2020-11-04 /pmc/articles/PMC7643495/ /pubmed/33148690 http://dx.doi.org/10.1136/bmjdrc-2020-001779 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Pathophysiology/Complications
Taylor, Guy S
Moser, Othmar
Smith, Kieran
Shaw, Andy
Tang, Jonathan C Y
Fraser, William D
Eckstein, Max L
Aziz, Faisal
Stevenson, Emma J
Shaw, James A
West, Daniel J
Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case–control study
title Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case–control study
title_full Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case–control study
title_fullStr Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case–control study
title_full_unstemmed Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case–control study
title_short Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case–control study
title_sort bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case–control study
topic Pathophysiology/Complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643495/
https://www.ncbi.nlm.nih.gov/pubmed/33148690
http://dx.doi.org/10.1136/bmjdrc-2020-001779
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