Cargando…

Postmortem CT lung findings in decedents with Covid-19: A review of 14 decedents and potential triage implications

OBJECTIVE: Computed tomography has significant utility as a diagnostic tool for coronavirus disease 2019 (COVID-19) in the clinical setting. COVID-19 deaths are sometimes examined by forensic pathologists, often in the setting of an unknown diagnosis. We assessed the utility of postmortem computed t...

Descripción completa

Detalles Bibliográficos
Autores principales: Helmrich, Emily, Decker, Lauren, Adolphi, Natalie, Makino, Yohsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643627/
http://dx.doi.org/10.1016/j.fri.2020.200419
_version_ 1783606314561175552
author Helmrich, Emily
Decker, Lauren
Adolphi, Natalie
Makino, Yohsuke
author_facet Helmrich, Emily
Decker, Lauren
Adolphi, Natalie
Makino, Yohsuke
author_sort Helmrich, Emily
collection PubMed
description OBJECTIVE: Computed tomography has significant utility as a diagnostic tool for coronavirus disease 2019 (COVID-19) in the clinical setting. COVID-19 deaths are sometimes examined by forensic pathologists, often in the setting of an unknown diagnosis. We assessed the utility of postmortem computed tomography (PMCT) for use as a triage tool for these autopsy examinations. MATERIALS AND METHODS: We reviewed PMCT findings in 14 and histopathology in 11 decedents who were positive for COVID-19. RESULTS: The predominant imaging findings were bilateral mixed densities, in either a diffuse or peripheral distribution, with traction bronchiectasis, and/or crazy paving. In particular, traction bronchiectasis, ill-defined rounded consolidations, and reverse halo sign are useful when distinguishing from other postmortem changes. CONCLUSION: We conclude that triage with a PMCT may aid the forensic pathologist in diagnosing possible COVID-19 infection prior to autopsy examination.
format Online
Article
Text
id pubmed-7643627
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-76436272020-11-06 Postmortem CT lung findings in decedents with Covid-19: A review of 14 decedents and potential triage implications Helmrich, Emily Decker, Lauren Adolphi, Natalie Makino, Yohsuke Forensic Imaging Article OBJECTIVE: Computed tomography has significant utility as a diagnostic tool for coronavirus disease 2019 (COVID-19) in the clinical setting. COVID-19 deaths are sometimes examined by forensic pathologists, often in the setting of an unknown diagnosis. We assessed the utility of postmortem computed tomography (PMCT) for use as a triage tool for these autopsy examinations. MATERIALS AND METHODS: We reviewed PMCT findings in 14 and histopathology in 11 decedents who were positive for COVID-19. RESULTS: The predominant imaging findings were bilateral mixed densities, in either a diffuse or peripheral distribution, with traction bronchiectasis, and/or crazy paving. In particular, traction bronchiectasis, ill-defined rounded consolidations, and reverse halo sign are useful when distinguishing from other postmortem changes. CONCLUSION: We conclude that triage with a PMCT may aid the forensic pathologist in diagnosing possible COVID-19 infection prior to autopsy examination. Elsevier Ltd. 2020-12 2020-11-05 /pmc/articles/PMC7643627/ http://dx.doi.org/10.1016/j.fri.2020.200419 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Helmrich, Emily
Decker, Lauren
Adolphi, Natalie
Makino, Yohsuke
Postmortem CT lung findings in decedents with Covid-19: A review of 14 decedents and potential triage implications
title Postmortem CT lung findings in decedents with Covid-19: A review of 14 decedents and potential triage implications
title_full Postmortem CT lung findings in decedents with Covid-19: A review of 14 decedents and potential triage implications
title_fullStr Postmortem CT lung findings in decedents with Covid-19: A review of 14 decedents and potential triage implications
title_full_unstemmed Postmortem CT lung findings in decedents with Covid-19: A review of 14 decedents and potential triage implications
title_short Postmortem CT lung findings in decedents with Covid-19: A review of 14 decedents and potential triage implications
title_sort postmortem ct lung findings in decedents with covid-19: a review of 14 decedents and potential triage implications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643627/
http://dx.doi.org/10.1016/j.fri.2020.200419
work_keys_str_mv AT helmrichemily postmortemctlungfindingsindecedentswithcovid19areviewof14decedentsandpotentialtriageimplications
AT deckerlauren postmortemctlungfindingsindecedentswithcovid19areviewof14decedentsandpotentialtriageimplications
AT adolphinatalie postmortemctlungfindingsindecedentswithcovid19areviewof14decedentsandpotentialtriageimplications
AT makinoyohsuke postmortemctlungfindingsindecedentswithcovid19areviewof14decedentsandpotentialtriageimplications