The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design

The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly...

Descripción completa

Detalles Bibliográficos
Autores principales: Groves, Danielle C., Rowland-Jones, Sarah L., Angyal, Adrienn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643658/
https://www.ncbi.nlm.nih.gov/pubmed/33199022
http://dx.doi.org/10.1016/j.bbrc.2020.10.109
_version_ 1783606321255284736
author Groves, Danielle C.
Rowland-Jones, Sarah L.
Angyal, Adrienn
author_facet Groves, Danielle C.
Rowland-Jones, Sarah L.
Angyal, Adrienn
author_sort Groves, Danielle C.
collection PubMed
description The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.
format Online
Article
Text
id pubmed-7643658
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-76436582020-11-06 The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design Groves, Danielle C. Rowland-Jones, Sarah L. Angyal, Adrienn Biochem Biophys Res Commun Article The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response. Elsevier Inc. 2021-01-29 2020-11-05 /pmc/articles/PMC7643658/ /pubmed/33199022 http://dx.doi.org/10.1016/j.bbrc.2020.10.109 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Groves, Danielle C.
Rowland-Jones, Sarah L.
Angyal, Adrienn
The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design
title The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design
title_full The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design
title_fullStr The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design
title_full_unstemmed The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design
title_short The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design
title_sort d614g mutations in the sars-cov-2 spike protein: implications for viral infectivity, disease severity and vaccine design
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643658/
https://www.ncbi.nlm.nih.gov/pubmed/33199022
http://dx.doi.org/10.1016/j.bbrc.2020.10.109
work_keys_str_mv AT grovesdaniellec thed614gmutationsinthesarscov2spikeproteinimplicationsforviralinfectivitydiseaseseverityandvaccinedesign
AT rowlandjonessarahl thed614gmutationsinthesarscov2spikeproteinimplicationsforviralinfectivitydiseaseseverityandvaccinedesign
AT angyaladrienn thed614gmutationsinthesarscov2spikeproteinimplicationsforviralinfectivitydiseaseseverityandvaccinedesign
AT grovesdaniellec d614gmutationsinthesarscov2spikeproteinimplicationsforviralinfectivitydiseaseseverityandvaccinedesign
AT rowlandjonessarahl d614gmutationsinthesarscov2spikeproteinimplicationsforviralinfectivitydiseaseseverityandvaccinedesign
AT angyaladrienn d614gmutationsinthesarscov2spikeproteinimplicationsforviralinfectivitydiseaseseverityandvaccinedesign

Ejemplares similares