Host-directed editing of the SARS-CoV-2 genome

The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In th...

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Detalles Bibliográficos
Autores principales: Mourier, Tobias, Sadykov, Mukhtar, Carr, Michael J., Gonzalez, Gabriel, Hall, William W., Pain, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643664/
https://www.ncbi.nlm.nih.gov/pubmed/33234239
http://dx.doi.org/10.1016/j.bbrc.2020.10.092
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author Mourier, Tobias
Sadykov, Mukhtar
Carr, Michael J.
Gonzalez, Gabriel
Hall, William W.
Pain, Arnab
author_facet Mourier, Tobias
Sadykov, Mukhtar
Carr, Michael J.
Gonzalez, Gabriel
Hall, William W.
Pain, Arnab
author_sort Mourier, Tobias
collection PubMed
description The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
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spelling pubmed-76436642020-11-06 Host-directed editing of the SARS-CoV-2 genome Mourier, Tobias Sadykov, Mukhtar Carr, Michael J. Gonzalez, Gabriel Hall, William W. Pain, Arnab Biochem Biophys Res Commun Article The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution. The Authors. Published by Elsevier Inc. 2021-01-29 2020-11-05 /pmc/articles/PMC7643664/ /pubmed/33234239 http://dx.doi.org/10.1016/j.bbrc.2020.10.092 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mourier, Tobias
Sadykov, Mukhtar
Carr, Michael J.
Gonzalez, Gabriel
Hall, William W.
Pain, Arnab
Host-directed editing of the SARS-CoV-2 genome
title Host-directed editing of the SARS-CoV-2 genome
title_full Host-directed editing of the SARS-CoV-2 genome
title_fullStr Host-directed editing of the SARS-CoV-2 genome
title_full_unstemmed Host-directed editing of the SARS-CoV-2 genome
title_short Host-directed editing of the SARS-CoV-2 genome
title_sort host-directed editing of the sars-cov-2 genome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643664/
https://www.ncbi.nlm.nih.gov/pubmed/33234239
http://dx.doi.org/10.1016/j.bbrc.2020.10.092
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