Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a

The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, i...

Descripción completa

Detalles Bibliográficos
Autores principales: Popping, Stephanie, Verwijs, Rosanne, Cuypers, Lize, Claassen, Mark A, van den Berk, Guido E, De Weggheleire, Anja, Arends, Joop E, Boerekamps, Anne, Molenkamp, Richard, Koopmans, Marion P, Verbon, Annelies, Boucher, Charles A B, Rijnders, Bart J, van de Vijver, David A M C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Online Only Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643739/
https://www.ncbi.nlm.nih.gov/pubmed/32055843
http://dx.doi.org/10.1093/cid/ciaa145
Descripción
Sumario:The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

Ejemplares similares