Variant analysis of 1,040 SARS-CoV-2 genomes

The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed...

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Detalles Bibliográficos
Autores principales: Rouchka, Eric C., Chariker, Julia H., Chung, Donghoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643988/
https://www.ncbi.nlm.nih.gov/pubmed/33152019
http://dx.doi.org/10.1371/journal.pone.0241535
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author Rouchka, Eric C.
Chariker, Julia H.
Chung, Donghoon
author_facet Rouchka, Eric C.
Chariker, Julia H.
Chung, Donghoon
author_sort Rouchka, Eric C.
collection PubMed
description The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed a comparative analysis of the sequences, in order to detect common mutations within the population. Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5’ untranslated region (UTR), 152 within the 3’UTR, 2 within intergenic regions and 34 within coding sequences.
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spelling pubmed-76439882020-11-16 Variant analysis of 1,040 SARS-CoV-2 genomes Rouchka, Eric C. Chariker, Julia H. Chung, Donghoon PLoS One Research Article The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed a comparative analysis of the sequences, in order to detect common mutations within the population. Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5’ untranslated region (UTR), 152 within the 3’UTR, 2 within intergenic regions and 34 within coding sequences. Public Library of Science 2020-11-05 /pmc/articles/PMC7643988/ /pubmed/33152019 http://dx.doi.org/10.1371/journal.pone.0241535 Text en © 2020 Rouchka et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rouchka, Eric C.
Chariker, Julia H.
Chung, Donghoon
Variant analysis of 1,040 SARS-CoV-2 genomes
title Variant analysis of 1,040 SARS-CoV-2 genomes
title_full Variant analysis of 1,040 SARS-CoV-2 genomes
title_fullStr Variant analysis of 1,040 SARS-CoV-2 genomes
title_full_unstemmed Variant analysis of 1,040 SARS-CoV-2 genomes
title_short Variant analysis of 1,040 SARS-CoV-2 genomes
title_sort variant analysis of 1,040 sars-cov-2 genomes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643988/
https://www.ncbi.nlm.nih.gov/pubmed/33152019
http://dx.doi.org/10.1371/journal.pone.0241535
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