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Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants

INTRODUCTION: Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this association and whether older age was associated with increased mortality risk in the absence of other risk factors. METHODS: In UK Biobank, a population cohort st...

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Autores principales: Ho, Frederick K., Petermann-Rocha, Fanny, Gray, Stuart R., Jani, Bhautesh D., Katikireddi, S. Vittal, Niedzwiedz, Claire L., Foster, Hamish, Hastie, Claire E., Mackay, Daniel F., Gill, Jason M. R., O'Donnell, Catherine, Welsh, Paul, Mair, Frances, Sattar, Naveed, Celis-Morales, Carlos A., Pell, Jill P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644030/
https://www.ncbi.nlm.nih.gov/pubmed/33152008
http://dx.doi.org/10.1371/journal.pone.0241824
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author Ho, Frederick K.
Petermann-Rocha, Fanny
Gray, Stuart R.
Jani, Bhautesh D.
Katikireddi, S. Vittal
Niedzwiedz, Claire L.
Foster, Hamish
Hastie, Claire E.
Mackay, Daniel F.
Gill, Jason M. R.
O'Donnell, Catherine
Welsh, Paul
Mair, Frances
Sattar, Naveed
Celis-Morales, Carlos A.
Pell, Jill P.
author_facet Ho, Frederick K.
Petermann-Rocha, Fanny
Gray, Stuart R.
Jani, Bhautesh D.
Katikireddi, S. Vittal
Niedzwiedz, Claire L.
Foster, Hamish
Hastie, Claire E.
Mackay, Daniel F.
Gill, Jason M. R.
O'Donnell, Catherine
Welsh, Paul
Mair, Frances
Sattar, Naveed
Celis-Morales, Carlos A.
Pell, Jill P.
author_sort Ho, Frederick K.
collection PubMed
description INTRODUCTION: Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this association and whether older age was associated with increased mortality risk in the absence of other risk factors. METHODS: In UK Biobank, a population cohort study, baseline data were linked to COVID-19 deaths. Poisson regression was used to study the association between current age and COVID-19 mortality. RESULTS: Among eligible participants, 438 (0.09%) died of COVID-19. Current age was associated exponentially with COVID-19 mortality. Overall, participants aged ≥75 years were at 13-fold (95% CI 9.13–17.85) mortality risk compared with those <65 years. Low forced expiratory volume in 1 second, high systolic blood pressure, low handgrip strength, and multiple long-term conditions were significant mediators, and collectively explained 39.3% of their excess risk. The associations between these risk factors and COVID-19 mortality were stronger among older participants. Participants aged ≥75 without additional risk factors were at 4-fold risk (95% CI 1.57–9.96, P = 0.004) compared with all participants aged <65 years. CONCLUSIONS: Higher COVID-19 mortality among older adults was partially explained by other risk factors. ‘Healthy’ older adults were at much lower risk. Nonetheless, older age was an independent risk factor for COVID-19 mortality.
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spelling pubmed-76440302020-11-16 Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants Ho, Frederick K. Petermann-Rocha, Fanny Gray, Stuart R. Jani, Bhautesh D. Katikireddi, S. Vittal Niedzwiedz, Claire L. Foster, Hamish Hastie, Claire E. Mackay, Daniel F. Gill, Jason M. R. O'Donnell, Catherine Welsh, Paul Mair, Frances Sattar, Naveed Celis-Morales, Carlos A. Pell, Jill P. PLoS One Research Article INTRODUCTION: Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this association and whether older age was associated with increased mortality risk in the absence of other risk factors. METHODS: In UK Biobank, a population cohort study, baseline data were linked to COVID-19 deaths. Poisson regression was used to study the association between current age and COVID-19 mortality. RESULTS: Among eligible participants, 438 (0.09%) died of COVID-19. Current age was associated exponentially with COVID-19 mortality. Overall, participants aged ≥75 years were at 13-fold (95% CI 9.13–17.85) mortality risk compared with those <65 years. Low forced expiratory volume in 1 second, high systolic blood pressure, low handgrip strength, and multiple long-term conditions were significant mediators, and collectively explained 39.3% of their excess risk. The associations between these risk factors and COVID-19 mortality were stronger among older participants. Participants aged ≥75 without additional risk factors were at 4-fold risk (95% CI 1.57–9.96, P = 0.004) compared with all participants aged <65 years. CONCLUSIONS: Higher COVID-19 mortality among older adults was partially explained by other risk factors. ‘Healthy’ older adults were at much lower risk. Nonetheless, older age was an independent risk factor for COVID-19 mortality. Public Library of Science 2020-11-05 /pmc/articles/PMC7644030/ /pubmed/33152008 http://dx.doi.org/10.1371/journal.pone.0241824 Text en © 2020 Ho et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ho, Frederick K.
Petermann-Rocha, Fanny
Gray, Stuart R.
Jani, Bhautesh D.
Katikireddi, S. Vittal
Niedzwiedz, Claire L.
Foster, Hamish
Hastie, Claire E.
Mackay, Daniel F.
Gill, Jason M. R.
O'Donnell, Catherine
Welsh, Paul
Mair, Frances
Sattar, Naveed
Celis-Morales, Carlos A.
Pell, Jill P.
Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants
title Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants
title_full Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants
title_fullStr Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants
title_full_unstemmed Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants
title_short Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants
title_sort is older age associated with covid-19 mortality in the absence of other risk factors? general population cohort study of 470,034 participants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644030/
https://www.ncbi.nlm.nih.gov/pubmed/33152008
http://dx.doi.org/10.1371/journal.pone.0241824
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