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A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study

The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need for immediate targeted actions. We designed a longitudinal study in a hot outbreak zone to analyze the serial findings between infected patients for detecting te...

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Autores principales: Sami, Ramin, Soltaninejad, Forogh, Amra, Babak, Naderi, Zohre, Haghjooy Javanmard, Shaghayegh, Iraj, Bijan, Haji Ahmadi, Somayeh, Shayganfar, Azin, Dehghan, Mehrnegar, Khademi, Nilufar, Sadat Hosseini, Nastaran, Mortazavi, Mojgan, Mansourian, Marjan, Mañanas, Miquel Angel, Marateb, Hamid Reza, Adibi, Peyman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644058/
https://www.ncbi.nlm.nih.gov/pubmed/33151983
http://dx.doi.org/10.1371/journal.pone.0241537
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author Sami, Ramin
Soltaninejad, Forogh
Amra, Babak
Naderi, Zohre
Haghjooy Javanmard, Shaghayegh
Iraj, Bijan
Haji Ahmadi, Somayeh
Shayganfar, Azin
Dehghan, Mehrnegar
Khademi, Nilufar
Sadat Hosseini, Nastaran
Mortazavi, Mojgan
Mansourian, Marjan
Mañanas, Miquel Angel
Marateb, Hamid Reza
Adibi, Peyman
author_facet Sami, Ramin
Soltaninejad, Forogh
Amra, Babak
Naderi, Zohre
Haghjooy Javanmard, Shaghayegh
Iraj, Bijan
Haji Ahmadi, Somayeh
Shayganfar, Azin
Dehghan, Mehrnegar
Khademi, Nilufar
Sadat Hosseini, Nastaran
Mortazavi, Mojgan
Mansourian, Marjan
Mañanas, Miquel Angel
Marateb, Hamid Reza
Adibi, Peyman
author_sort Sami, Ramin
collection PubMed
description The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need for immediate targeted actions. We designed a longitudinal study in a hot outbreak zone to analyze the serial findings between infected patients for detecting temporal changes from February 2020. In a hospital-based open-cohort study, patients are followed from admission until one year from their discharge (the 1st, 4th, 12th weeks, and the first year). The patient recruitment phase finished at the end of August 2020, and the follow-up continues by the end of August 2021. The measurements included demographic, socio-economics, symptoms, health service diagnosis and treatment, contact history, and psychological variables. The signs improvement, death, length of stay in hospital were considered primary, and impaired pulmonary function and psychotic disorders were considered main secondary outcomes. Moreover, clinical symptoms and respiratory functions are being determined in such follow-ups. Among the first 600 COVID-19 cases, 490 patients with complete information (39% female; the average age of 57±15 years) were analyzed. Seven percent of these patients died. The three main leading causes of admission were: fever (77%), dry cough (73%), and fatigue (69%). The most prevalent comorbidities between COVID-19 patients were hypertension (35%), diabetes (28%), and ischemic heart disease (14%). The percentage of primary composite endpoints (PCEP), defined as death, the use of mechanical ventilation, or admission to an intensive care unit was 18%. The Cox Proportional-Hazards Model for PCEP indicated the following significant risk factors: Oxygen saturation < 80% (HR = 6.3; [CI 95%: 2.5,15.5]), lymphopenia (HR = 3.5; [CI 95%: 2.2,5.5]), Oxygen saturation 80%-90% (HR = 2.5; [CI 95%: 1.1,5.8]), and thrombocytopenia (HR = 1.6; [CI 95%: 1.1,2.5]). This long-term prospective Cohort may support healthcare professionals in the management of resources following this pandemic.
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spelling pubmed-76440582020-11-16 A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study Sami, Ramin Soltaninejad, Forogh Amra, Babak Naderi, Zohre Haghjooy Javanmard, Shaghayegh Iraj, Bijan Haji Ahmadi, Somayeh Shayganfar, Azin Dehghan, Mehrnegar Khademi, Nilufar Sadat Hosseini, Nastaran Mortazavi, Mojgan Mansourian, Marjan Mañanas, Miquel Angel Marateb, Hamid Reza Adibi, Peyman PLoS One Research Article The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need for immediate targeted actions. We designed a longitudinal study in a hot outbreak zone to analyze the serial findings between infected patients for detecting temporal changes from February 2020. In a hospital-based open-cohort study, patients are followed from admission until one year from their discharge (the 1st, 4th, 12th weeks, and the first year). The patient recruitment phase finished at the end of August 2020, and the follow-up continues by the end of August 2021. The measurements included demographic, socio-economics, symptoms, health service diagnosis and treatment, contact history, and psychological variables. The signs improvement, death, length of stay in hospital were considered primary, and impaired pulmonary function and psychotic disorders were considered main secondary outcomes. Moreover, clinical symptoms and respiratory functions are being determined in such follow-ups. Among the first 600 COVID-19 cases, 490 patients with complete information (39% female; the average age of 57±15 years) were analyzed. Seven percent of these patients died. The three main leading causes of admission were: fever (77%), dry cough (73%), and fatigue (69%). The most prevalent comorbidities between COVID-19 patients were hypertension (35%), diabetes (28%), and ischemic heart disease (14%). The percentage of primary composite endpoints (PCEP), defined as death, the use of mechanical ventilation, or admission to an intensive care unit was 18%. The Cox Proportional-Hazards Model for PCEP indicated the following significant risk factors: Oxygen saturation < 80% (HR = 6.3; [CI 95%: 2.5,15.5]), lymphopenia (HR = 3.5; [CI 95%: 2.2,5.5]), Oxygen saturation 80%-90% (HR = 2.5; [CI 95%: 1.1,5.8]), and thrombocytopenia (HR = 1.6; [CI 95%: 1.1,2.5]). This long-term prospective Cohort may support healthcare professionals in the management of resources following this pandemic. Public Library of Science 2020-11-05 /pmc/articles/PMC7644058/ /pubmed/33151983 http://dx.doi.org/10.1371/journal.pone.0241537 Text en © 2020 Sami et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sami, Ramin
Soltaninejad, Forogh
Amra, Babak
Naderi, Zohre
Haghjooy Javanmard, Shaghayegh
Iraj, Bijan
Haji Ahmadi, Somayeh
Shayganfar, Azin
Dehghan, Mehrnegar
Khademi, Nilufar
Sadat Hosseini, Nastaran
Mortazavi, Mojgan
Mansourian, Marjan
Mañanas, Miquel Angel
Marateb, Hamid Reza
Adibi, Peyman
A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study
title A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study
title_full A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study
title_fullStr A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study
title_full_unstemmed A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study
title_short A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study
title_sort one-year hospital-based prospective covid-19 open-cohort in the eastern mediterranean region: the khorshid covid cohort (kcc) study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644058/
https://www.ncbi.nlm.nih.gov/pubmed/33151983
http://dx.doi.org/10.1371/journal.pone.0241537
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