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A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study
The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need for immediate targeted actions. We designed a longitudinal study in a hot outbreak zone to analyze the serial findings between infected patients for detecting te...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644058/ https://www.ncbi.nlm.nih.gov/pubmed/33151983 http://dx.doi.org/10.1371/journal.pone.0241537 |
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author | Sami, Ramin Soltaninejad, Forogh Amra, Babak Naderi, Zohre Haghjooy Javanmard, Shaghayegh Iraj, Bijan Haji Ahmadi, Somayeh Shayganfar, Azin Dehghan, Mehrnegar Khademi, Nilufar Sadat Hosseini, Nastaran Mortazavi, Mojgan Mansourian, Marjan Mañanas, Miquel Angel Marateb, Hamid Reza Adibi, Peyman |
author_facet | Sami, Ramin Soltaninejad, Forogh Amra, Babak Naderi, Zohre Haghjooy Javanmard, Shaghayegh Iraj, Bijan Haji Ahmadi, Somayeh Shayganfar, Azin Dehghan, Mehrnegar Khademi, Nilufar Sadat Hosseini, Nastaran Mortazavi, Mojgan Mansourian, Marjan Mañanas, Miquel Angel Marateb, Hamid Reza Adibi, Peyman |
author_sort | Sami, Ramin |
collection | PubMed |
description | The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need for immediate targeted actions. We designed a longitudinal study in a hot outbreak zone to analyze the serial findings between infected patients for detecting temporal changes from February 2020. In a hospital-based open-cohort study, patients are followed from admission until one year from their discharge (the 1st, 4th, 12th weeks, and the first year). The patient recruitment phase finished at the end of August 2020, and the follow-up continues by the end of August 2021. The measurements included demographic, socio-economics, symptoms, health service diagnosis and treatment, contact history, and psychological variables. The signs improvement, death, length of stay in hospital were considered primary, and impaired pulmonary function and psychotic disorders were considered main secondary outcomes. Moreover, clinical symptoms and respiratory functions are being determined in such follow-ups. Among the first 600 COVID-19 cases, 490 patients with complete information (39% female; the average age of 57±15 years) were analyzed. Seven percent of these patients died. The three main leading causes of admission were: fever (77%), dry cough (73%), and fatigue (69%). The most prevalent comorbidities between COVID-19 patients were hypertension (35%), diabetes (28%), and ischemic heart disease (14%). The percentage of primary composite endpoints (PCEP), defined as death, the use of mechanical ventilation, or admission to an intensive care unit was 18%. The Cox Proportional-Hazards Model for PCEP indicated the following significant risk factors: Oxygen saturation < 80% (HR = 6.3; [CI 95%: 2.5,15.5]), lymphopenia (HR = 3.5; [CI 95%: 2.2,5.5]), Oxygen saturation 80%-90% (HR = 2.5; [CI 95%: 1.1,5.8]), and thrombocytopenia (HR = 1.6; [CI 95%: 1.1,2.5]). This long-term prospective Cohort may support healthcare professionals in the management of resources following this pandemic. |
format | Online Article Text |
id | pubmed-7644058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76440582020-11-16 A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study Sami, Ramin Soltaninejad, Forogh Amra, Babak Naderi, Zohre Haghjooy Javanmard, Shaghayegh Iraj, Bijan Haji Ahmadi, Somayeh Shayganfar, Azin Dehghan, Mehrnegar Khademi, Nilufar Sadat Hosseini, Nastaran Mortazavi, Mojgan Mansourian, Marjan Mañanas, Miquel Angel Marateb, Hamid Reza Adibi, Peyman PLoS One Research Article The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need for immediate targeted actions. We designed a longitudinal study in a hot outbreak zone to analyze the serial findings between infected patients for detecting temporal changes from February 2020. In a hospital-based open-cohort study, patients are followed from admission until one year from their discharge (the 1st, 4th, 12th weeks, and the first year). The patient recruitment phase finished at the end of August 2020, and the follow-up continues by the end of August 2021. The measurements included demographic, socio-economics, symptoms, health service diagnosis and treatment, contact history, and psychological variables. The signs improvement, death, length of stay in hospital were considered primary, and impaired pulmonary function and psychotic disorders were considered main secondary outcomes. Moreover, clinical symptoms and respiratory functions are being determined in such follow-ups. Among the first 600 COVID-19 cases, 490 patients with complete information (39% female; the average age of 57±15 years) were analyzed. Seven percent of these patients died. The three main leading causes of admission were: fever (77%), dry cough (73%), and fatigue (69%). The most prevalent comorbidities between COVID-19 patients were hypertension (35%), diabetes (28%), and ischemic heart disease (14%). The percentage of primary composite endpoints (PCEP), defined as death, the use of mechanical ventilation, or admission to an intensive care unit was 18%. The Cox Proportional-Hazards Model for PCEP indicated the following significant risk factors: Oxygen saturation < 80% (HR = 6.3; [CI 95%: 2.5,15.5]), lymphopenia (HR = 3.5; [CI 95%: 2.2,5.5]), Oxygen saturation 80%-90% (HR = 2.5; [CI 95%: 1.1,5.8]), and thrombocytopenia (HR = 1.6; [CI 95%: 1.1,2.5]). This long-term prospective Cohort may support healthcare professionals in the management of resources following this pandemic. Public Library of Science 2020-11-05 /pmc/articles/PMC7644058/ /pubmed/33151983 http://dx.doi.org/10.1371/journal.pone.0241537 Text en © 2020 Sami et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sami, Ramin Soltaninejad, Forogh Amra, Babak Naderi, Zohre Haghjooy Javanmard, Shaghayegh Iraj, Bijan Haji Ahmadi, Somayeh Shayganfar, Azin Dehghan, Mehrnegar Khademi, Nilufar Sadat Hosseini, Nastaran Mortazavi, Mojgan Mansourian, Marjan Mañanas, Miquel Angel Marateb, Hamid Reza Adibi, Peyman A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study |
title | A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study |
title_full | A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study |
title_fullStr | A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study |
title_full_unstemmed | A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study |
title_short | A one-year hospital-based prospective COVID-19 open-cohort in the Eastern Mediterranean region: The Khorshid COVID Cohort (KCC) study |
title_sort | one-year hospital-based prospective covid-19 open-cohort in the eastern mediterranean region: the khorshid covid cohort (kcc) study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644058/ https://www.ncbi.nlm.nih.gov/pubmed/33151983 http://dx.doi.org/10.1371/journal.pone.0241537 |
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