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Circumventing colistin resistance by combining colistin and antimicrobial peptides to kill colistin-resistant and multidrug-resistant Gram-negative bacteria

OBJECTIVES: Colistin is a ‘last-line’ antibiotic used to treat multidrug-resistant Gram-negative bacteria, but colistin resistance has emerged. Colistin normally binds to the lipid A moiety on the bacterial outer membrane, where it then destroys the bacterial membrane. Mobilize colistin resistance (...

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Detalles Bibliográficos
Autores principales:	Witherell, Kaitlin S., Price, Jason, Bandaranayake, Ashok D., Olson, James, Call, Douglas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644326/ https://www.ncbi.nlm.nih.gov/pubmed/32512236 http://dx.doi.org/10.1016/j.jgar.2020.05.013

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