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A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function

Non-alcoholic fatty liver disease (NAFLD) has the potential to develop into hepatic steatosis and progress to terminal liver diseases such as cirrhosis and hepatocellular carcinoma. This human clinical study was aimed to demonstrate that SPB-201 (powdered-water extract of Artemisia annua) can improv...

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Autores principales: Han, Byoungduck, Kim, Seon-Mee, Nam, Ga Eun, Kim, Seon-Hee, Park, Su-Jin, Park, Young-Kyu, Baik, Hyun Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Clinical Nutrition 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644367/
https://www.ncbi.nlm.nih.gov/pubmed/33204666
http://dx.doi.org/10.7762/cnr.2020.9.4.258
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author Han, Byoungduck
Kim, Seon-Mee
Nam, Ga Eun
Kim, Seon-Hee
Park, Su-Jin
Park, Young-Kyu
Baik, Hyun Wook
author_facet Han, Byoungduck
Kim, Seon-Mee
Nam, Ga Eun
Kim, Seon-Hee
Park, Su-Jin
Park, Young-Kyu
Baik, Hyun Wook
author_sort Han, Byoungduck
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) has the potential to develop into hepatic steatosis and progress to terminal liver diseases such as cirrhosis and hepatocellular carcinoma. This human clinical study was aimed to demonstrate that SPB-201 (powdered-water extract of Artemisia annua) can improve liver function in subjects with non-alcoholic liver dysfunction at mild to moderate levels. A decrease of 271% in aspartate aminotransferase (AST) level and a significant decrease of 334% in alanine aminotransferase (ALT) level was observed in the test group as compared to the control group at the 4 weeks follow-up. In addition, after 8 weeks, decreases of 199% in AST level and 216% in ALT level were reported in the test group as compared to the control group. These results confirmed that SPB-201 intake significantly enhanced liver function and health. Moreover, the Multidimensional Fatigue Scale score of the test group decreased but that of the control group increased, implicating that SPB-201 also eliminated overall fatigue. No significant adverse events were observed among all subjects during the study. Taken together, our clinical study confirmed the excellent efficacy and safety of SPB-201 in liver function improvement, showing the possibility of SPB-201 as a functional food to restore liver dysfunction and treat liver diseases.
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spelling pubmed-76443672020-11-16 A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function Han, Byoungduck Kim, Seon-Mee Nam, Ga Eun Kim, Seon-Hee Park, Su-Jin Park, Young-Kyu Baik, Hyun Wook Clin Nutr Res Original Article Non-alcoholic fatty liver disease (NAFLD) has the potential to develop into hepatic steatosis and progress to terminal liver diseases such as cirrhosis and hepatocellular carcinoma. This human clinical study was aimed to demonstrate that SPB-201 (powdered-water extract of Artemisia annua) can improve liver function in subjects with non-alcoholic liver dysfunction at mild to moderate levels. A decrease of 271% in aspartate aminotransferase (AST) level and a significant decrease of 334% in alanine aminotransferase (ALT) level was observed in the test group as compared to the control group at the 4 weeks follow-up. In addition, after 8 weeks, decreases of 199% in AST level and 216% in ALT level were reported in the test group as compared to the control group. These results confirmed that SPB-201 intake significantly enhanced liver function and health. Moreover, the Multidimensional Fatigue Scale score of the test group decreased but that of the control group increased, implicating that SPB-201 also eliminated overall fatigue. No significant adverse events were observed among all subjects during the study. Taken together, our clinical study confirmed the excellent efficacy and safety of SPB-201 in liver function improvement, showing the possibility of SPB-201 as a functional food to restore liver dysfunction and treat liver diseases. Korean Society of Clinical Nutrition 2020-10-28 /pmc/articles/PMC7644367/ /pubmed/33204666 http://dx.doi.org/10.7762/cnr.2020.9.4.258 Text en Copyright © 2020. The Korean Society of Clinical Nutrition https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Han, Byoungduck
Kim, Seon-Mee
Nam, Ga Eun
Kim, Seon-Hee
Park, Su-Jin
Park, Young-Kyu
Baik, Hyun Wook
A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function
title A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function
title_full A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function
title_fullStr A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function
title_full_unstemmed A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function
title_short A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function
title_sort randomized, double-blind, placebo-controlled, multi-centered clinical study to evaluate the efficacy and safety of artemisia annua l. extract for improvement of liver function
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644367/
https://www.ncbi.nlm.nih.gov/pubmed/33204666
http://dx.doi.org/10.7762/cnr.2020.9.4.258
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