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Anti-Inflammatory Diets and Schizophrenia

Schizophrenia is a mental illness characterized by symptoms such as hallucinations, delusions, disorganized speech, disorganized or catatonic behavior, and negative symptoms (emotional flatness, apathy, and lack of speech). It causes social and economic burdens to patients and their family. Although...

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Autores principales: Cha, Hee Yun, Yang, Soo Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Clinical Nutrition 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644368/
https://www.ncbi.nlm.nih.gov/pubmed/33204665
http://dx.doi.org/10.7762/cnr.2020.9.4.241
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author Cha, Hee Yun
Yang, Soo Jin
author_facet Cha, Hee Yun
Yang, Soo Jin
author_sort Cha, Hee Yun
collection PubMed
description Schizophrenia is a mental illness characterized by symptoms such as hallucinations, delusions, disorganized speech, disorganized or catatonic behavior, and negative symptoms (emotional flatness, apathy, and lack of speech). It causes social and economic burdens to patients and their family. Although etiology of schizophrenia is still uncertain, dopamine dysregulation is traditionally considered as a main etiological factor of schizophrenia, which has been utilized to develop drugs for treating schizophrenia. Recently, inflammation has presented being a risk factor for schizophrenia in that neuroinflammation contributes to the pathophysiology of schizophrenia and the exacerbation of symptom severity. Various factors including diet can regulate inflammatory state. Specific foods or dietary patterns have anti- or pro-inflammatory potentials. Increased levels of pro-inflammatory cytokines and microglia activation have been reported in schizophrenia populations and were related to the pathogenesis of schizophrenia. Omega-3 fatty acids were often recommended to schizophrenia patients because of their anti-inflammatory activities. In this review, we investigate the inflammation-related pathogenesis of schizophrenia and summarize potential nutritional approaches to inhibit the manifestation of symptoms and to alleviate symptom severity using anti-inflammatory nutrients or functional components.
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spelling pubmed-76443682020-11-16 Anti-Inflammatory Diets and Schizophrenia Cha, Hee Yun Yang, Soo Jin Clin Nutr Res Review Article Schizophrenia is a mental illness characterized by symptoms such as hallucinations, delusions, disorganized speech, disorganized or catatonic behavior, and negative symptoms (emotional flatness, apathy, and lack of speech). It causes social and economic burdens to patients and their family. Although etiology of schizophrenia is still uncertain, dopamine dysregulation is traditionally considered as a main etiological factor of schizophrenia, which has been utilized to develop drugs for treating schizophrenia. Recently, inflammation has presented being a risk factor for schizophrenia in that neuroinflammation contributes to the pathophysiology of schizophrenia and the exacerbation of symptom severity. Various factors including diet can regulate inflammatory state. Specific foods or dietary patterns have anti- or pro-inflammatory potentials. Increased levels of pro-inflammatory cytokines and microglia activation have been reported in schizophrenia populations and were related to the pathogenesis of schizophrenia. Omega-3 fatty acids were often recommended to schizophrenia patients because of their anti-inflammatory activities. In this review, we investigate the inflammation-related pathogenesis of schizophrenia and summarize potential nutritional approaches to inhibit the manifestation of symptoms and to alleviate symptom severity using anti-inflammatory nutrients or functional components. Korean Society of Clinical Nutrition 2020-10-28 /pmc/articles/PMC7644368/ /pubmed/33204665 http://dx.doi.org/10.7762/cnr.2020.9.4.241 Text en Copyright © 2020. The Korean Society of Clinical Nutrition https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cha, Hee Yun
Yang, Soo Jin
Anti-Inflammatory Diets and Schizophrenia
title Anti-Inflammatory Diets and Schizophrenia
title_full Anti-Inflammatory Diets and Schizophrenia
title_fullStr Anti-Inflammatory Diets and Schizophrenia
title_full_unstemmed Anti-Inflammatory Diets and Schizophrenia
title_short Anti-Inflammatory Diets and Schizophrenia
title_sort anti-inflammatory diets and schizophrenia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644368/
https://www.ncbi.nlm.nih.gov/pubmed/33204665
http://dx.doi.org/10.7762/cnr.2020.9.4.241
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