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Parathyroid Hormone and 25-Hydroxyvitamin D Do Not Mediate the Association between Dietary Calcium, Protein and Vitamin D Intake and Adiposity and Lipid Profile in Patients with Type 2 Diabetes: a Structural Equation Modeling Approach
This study aimed to utilize structural equation modeling (SEM) techniques to determine the effects of dietary calcium, protein and vitamin D on adiposity and lipidemia and to assess mediatory effects of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25(OH)D) in patients with type 2 diabetes. In...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Clinical Nutrition
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644370/ https://www.ncbi.nlm.nih.gov/pubmed/33204667 http://dx.doi.org/10.7762/cnr.2020.9.4.271 |
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author | Janmohammadi, Parisa Djafari, Farhang Farsani, Gholamreza Mohammadi Shab-Bidar, Sakineh Mehrizi, Ali Asghar Haeri |
author_facet | Janmohammadi, Parisa Djafari, Farhang Farsani, Gholamreza Mohammadi Shab-Bidar, Sakineh Mehrizi, Ali Asghar Haeri |
author_sort | Janmohammadi, Parisa |
collection | PubMed |
description | This study aimed to utilize structural equation modeling (SEM) techniques to determine the effects of dietary calcium, protein and vitamin D on adiposity and lipidemia and to assess mediatory effects of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25(OH)D) in patients with type 2 diabetes. In this cross-sectional study, a total of 150 diabetic patients (93 females and 57 males) were randomly selected. Anthropometric measures, biochemical analyses, and fat mass percent were recorded. Nutritional data were collected. SEM was performed. Based on the primary hypothesis, adiposity and lipidemia were fitted in a model. The direct effects of dietary calcium (λ = –0.165, p value = 0.002) and PTH (λ = –0.143, p value = 0.011) were significantly associated with lipidemia. There were no significant effects for dietary protein on PTH (λ = –0.270, p value = 0.057), 25(OH)D (λ = –0.071, p value = 0.613), lipidemia (λ = –0.044; p value = 0.638) or adiposity (λ = –0.009, p value = 0.949) as well as for dietary vitamin D on PTH (λ = –0.119, p value = 0.194), 25(OH)D (λ = 0.023, p value = 0.806), lipidemia (λ = 0.034, p value = 0.587) or adiposity (λ = –0.221, p value = 0.118). The correlation between calcium intake and lipidemia, and adiposity are not mediated by 25(OH)D and PTH. There were the direct effects of dietary calcium on adiposity in patients with type 2 diabetes. The model can be tested in future longitudinal and intervention studies to identify the predictors of obesity. |
format | Online Article Text |
id | pubmed-7644370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society of Clinical Nutrition |
record_format | MEDLINE/PubMed |
spelling | pubmed-76443702020-11-16 Parathyroid Hormone and 25-Hydroxyvitamin D Do Not Mediate the Association between Dietary Calcium, Protein and Vitamin D Intake and Adiposity and Lipid Profile in Patients with Type 2 Diabetes: a Structural Equation Modeling Approach Janmohammadi, Parisa Djafari, Farhang Farsani, Gholamreza Mohammadi Shab-Bidar, Sakineh Mehrizi, Ali Asghar Haeri Clin Nutr Res Original Article This study aimed to utilize structural equation modeling (SEM) techniques to determine the effects of dietary calcium, protein and vitamin D on adiposity and lipidemia and to assess mediatory effects of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25(OH)D) in patients with type 2 diabetes. In this cross-sectional study, a total of 150 diabetic patients (93 females and 57 males) were randomly selected. Anthropometric measures, biochemical analyses, and fat mass percent were recorded. Nutritional data were collected. SEM was performed. Based on the primary hypothesis, adiposity and lipidemia were fitted in a model. The direct effects of dietary calcium (λ = –0.165, p value = 0.002) and PTH (λ = –0.143, p value = 0.011) were significantly associated with lipidemia. There were no significant effects for dietary protein on PTH (λ = –0.270, p value = 0.057), 25(OH)D (λ = –0.071, p value = 0.613), lipidemia (λ = –0.044; p value = 0.638) or adiposity (λ = –0.009, p value = 0.949) as well as for dietary vitamin D on PTH (λ = –0.119, p value = 0.194), 25(OH)D (λ = 0.023, p value = 0.806), lipidemia (λ = 0.034, p value = 0.587) or adiposity (λ = –0.221, p value = 0.118). The correlation between calcium intake and lipidemia, and adiposity are not mediated by 25(OH)D and PTH. There were the direct effects of dietary calcium on adiposity in patients with type 2 diabetes. The model can be tested in future longitudinal and intervention studies to identify the predictors of obesity. Korean Society of Clinical Nutrition 2020-10-28 /pmc/articles/PMC7644370/ /pubmed/33204667 http://dx.doi.org/10.7762/cnr.2020.9.4.271 Text en Copyright © 2020. The Korean Society of Clinical Nutrition https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Janmohammadi, Parisa Djafari, Farhang Farsani, Gholamreza Mohammadi Shab-Bidar, Sakineh Mehrizi, Ali Asghar Haeri Parathyroid Hormone and 25-Hydroxyvitamin D Do Not Mediate the Association between Dietary Calcium, Protein and Vitamin D Intake and Adiposity and Lipid Profile in Patients with Type 2 Diabetes: a Structural Equation Modeling Approach |
title | Parathyroid Hormone and 25-Hydroxyvitamin D Do Not Mediate the Association between Dietary Calcium, Protein and Vitamin D Intake and Adiposity and Lipid Profile in Patients with Type 2 Diabetes: a Structural Equation Modeling Approach |
title_full | Parathyroid Hormone and 25-Hydroxyvitamin D Do Not Mediate the Association between Dietary Calcium, Protein and Vitamin D Intake and Adiposity and Lipid Profile in Patients with Type 2 Diabetes: a Structural Equation Modeling Approach |
title_fullStr | Parathyroid Hormone and 25-Hydroxyvitamin D Do Not Mediate the Association between Dietary Calcium, Protein and Vitamin D Intake and Adiposity and Lipid Profile in Patients with Type 2 Diabetes: a Structural Equation Modeling Approach |
title_full_unstemmed | Parathyroid Hormone and 25-Hydroxyvitamin D Do Not Mediate the Association between Dietary Calcium, Protein and Vitamin D Intake and Adiposity and Lipid Profile in Patients with Type 2 Diabetes: a Structural Equation Modeling Approach |
title_short | Parathyroid Hormone and 25-Hydroxyvitamin D Do Not Mediate the Association between Dietary Calcium, Protein and Vitamin D Intake and Adiposity and Lipid Profile in Patients with Type 2 Diabetes: a Structural Equation Modeling Approach |
title_sort | parathyroid hormone and 25-hydroxyvitamin d do not mediate the association between dietary calcium, protein and vitamin d intake and adiposity and lipid profile in patients with type 2 diabetes: a structural equation modeling approach |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644370/ https://www.ncbi.nlm.nih.gov/pubmed/33204667 http://dx.doi.org/10.7762/cnr.2020.9.4.271 |
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