Regression and Stabilization of Coronary Vulnerable Plaque by Evolocumab as Assessed by Multidetector Row Computed Tomography

A 65-year-old man was followed for his coronary conditions using 320-multi detector row computed tomography (MDCT) for 30 months. He had soft plaque in the right coronary artery (RCA) [mean density of plaque was 22 hounsfield units (HU)]. His initial serum low-density lipoprotein cholesterol (LDL-C)...

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Autores principales: Shiga, Yuhei, Idemoto, Yoshiaki, Tashiro, Kohei, Imaizumi, Tomoki, Ueda, Yoko, Yano, Yuiko, Norimatsu, Kenji, Nakamura, Ayumi, Miura, Shin-ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644491/
https://www.ncbi.nlm.nih.gov/pubmed/32611955
http://dx.doi.org/10.2169/internalmedicine.4436-20
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author Shiga, Yuhei
Idemoto, Yoshiaki
Tashiro, Kohei
Imaizumi, Tomoki
Ueda, Yoko
Yano, Yuiko
Norimatsu, Kenji
Nakamura, Ayumi
Miura, Shin-ichiro
author_facet Shiga, Yuhei
Idemoto, Yoshiaki
Tashiro, Kohei
Imaizumi, Tomoki
Ueda, Yoko
Yano, Yuiko
Norimatsu, Kenji
Nakamura, Ayumi
Miura, Shin-ichiro
author_sort Shiga, Yuhei
collection PubMed
description A 65-year-old man was followed for his coronary conditions using 320-multi detector row computed tomography (MDCT) for 30 months. He had soft plaque in the right coronary artery (RCA) [mean density of plaque was 22 hounsfield units (HU)]. His initial serum low-density lipoprotein cholesterol (LDL-C) was 72 mg/dL. After 30 months, his serum LDL-C was 26 mg/dL under 5.0 mg/day rosuvastatin and evolocumab 140 mg/2 weeks. MDCT showed a regression of the plaque in the RCA and the plaque density was 114 HU (intermediate plaque). In conclusion, intensive lipid-lowering therapy with evolocumab induced the regression and stabilization of coronary vulnerable plaque.
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spelling pubmed-76444912020-11-13 Regression and Stabilization of Coronary Vulnerable Plaque by Evolocumab as Assessed by Multidetector Row Computed Tomography Shiga, Yuhei Idemoto, Yoshiaki Tashiro, Kohei Imaizumi, Tomoki Ueda, Yoko Yano, Yuiko Norimatsu, Kenji Nakamura, Ayumi Miura, Shin-ichiro Intern Med Case Report A 65-year-old man was followed for his coronary conditions using 320-multi detector row computed tomography (MDCT) for 30 months. He had soft plaque in the right coronary artery (RCA) [mean density of plaque was 22 hounsfield units (HU)]. His initial serum low-density lipoprotein cholesterol (LDL-C) was 72 mg/dL. After 30 months, his serum LDL-C was 26 mg/dL under 5.0 mg/day rosuvastatin and evolocumab 140 mg/2 weeks. MDCT showed a regression of the plaque in the RCA and the plaque density was 114 HU (intermediate plaque). In conclusion, intensive lipid-lowering therapy with evolocumab induced the regression and stabilization of coronary vulnerable plaque. The Japanese Society of Internal Medicine 2020-06-30 2020-10-01 /pmc/articles/PMC7644491/ /pubmed/32611955 http://dx.doi.org/10.2169/internalmedicine.4436-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shiga, Yuhei
Idemoto, Yoshiaki
Tashiro, Kohei
Imaizumi, Tomoki
Ueda, Yoko
Yano, Yuiko
Norimatsu, Kenji
Nakamura, Ayumi
Miura, Shin-ichiro
Regression and Stabilization of Coronary Vulnerable Plaque by Evolocumab as Assessed by Multidetector Row Computed Tomography
title Regression and Stabilization of Coronary Vulnerable Plaque by Evolocumab as Assessed by Multidetector Row Computed Tomography
title_full Regression and Stabilization of Coronary Vulnerable Plaque by Evolocumab as Assessed by Multidetector Row Computed Tomography
title_fullStr Regression and Stabilization of Coronary Vulnerable Plaque by Evolocumab as Assessed by Multidetector Row Computed Tomography
title_full_unstemmed Regression and Stabilization of Coronary Vulnerable Plaque by Evolocumab as Assessed by Multidetector Row Computed Tomography
title_short Regression and Stabilization of Coronary Vulnerable Plaque by Evolocumab as Assessed by Multidetector Row Computed Tomography
title_sort regression and stabilization of coronary vulnerable plaque by evolocumab as assessed by multidetector row computed tomography
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644491/
https://www.ncbi.nlm.nih.gov/pubmed/32611955
http://dx.doi.org/10.2169/internalmedicine.4436-20
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