Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases

The selective arterial calcium stimulation test (SACST) is one of the most useful localization tests for insulinoma but can cause false-positive and/or unexpected multi arterial positive results that hamper clinical decisions. There are also several adverse effects, such as nausea and hypoglycemia,...

Descripción completa

Detalles Bibliográficos
Autores principales: Hatoko, Tomonobu, Murakami, Takaaki, Sone, Masakatsu, Yabe, Daisuke, Masui, Toshihiko, Nakamoto, Yuji, Furuta, Akihiro, Uza, Norimitsu, Kodama, Yuzo, Harada, Norio, Ogura, Masahito, Yasoda, Akihiro, Inagaki, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644493/
https://www.ncbi.nlm.nih.gov/pubmed/32611954
http://dx.doi.org/10.2169/internalmedicine.4396-20
_version_ 1783606469013274624
author Hatoko, Tomonobu
Murakami, Takaaki
Sone, Masakatsu
Yabe, Daisuke
Masui, Toshihiko
Nakamoto, Yuji
Furuta, Akihiro
Uza, Norimitsu
Kodama, Yuzo
Harada, Norio
Ogura, Masahito
Yasoda, Akihiro
Inagaki, Nobuya
author_facet Hatoko, Tomonobu
Murakami, Takaaki
Sone, Masakatsu
Yabe, Daisuke
Masui, Toshihiko
Nakamoto, Yuji
Furuta, Akihiro
Uza, Norimitsu
Kodama, Yuzo
Harada, Norio
Ogura, Masahito
Yasoda, Akihiro
Inagaki, Nobuya
author_sort Hatoko, Tomonobu
collection PubMed
description The selective arterial calcium stimulation test (SACST) is one of the most useful localization tests for insulinoma but can cause false-positive and/or unexpected multi arterial positive results that hamper clinical decisions. There are also several adverse effects, such as nausea and hypoglycemia, at the conventional dose (0.025 mEq/kg) of calcium injection. We herein report five consecutive insulinoma cases in which low-dose (0.005-0.007 mEq/kg) calcium injection for SACST led to successful insulinoma localization. No adverse effects of SACST were observed. In conclusion, a low-dose SACST can be a favorable option as an insulinoma localization test in terms of accuracy and safety.
format Online
Article
Text
id pubmed-7644493
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-76444932020-11-13 Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases Hatoko, Tomonobu Murakami, Takaaki Sone, Masakatsu Yabe, Daisuke Masui, Toshihiko Nakamoto, Yuji Furuta, Akihiro Uza, Norimitsu Kodama, Yuzo Harada, Norio Ogura, Masahito Yasoda, Akihiro Inagaki, Nobuya Intern Med Case Report The selective arterial calcium stimulation test (SACST) is one of the most useful localization tests for insulinoma but can cause false-positive and/or unexpected multi arterial positive results that hamper clinical decisions. There are also several adverse effects, such as nausea and hypoglycemia, at the conventional dose (0.025 mEq/kg) of calcium injection. We herein report five consecutive insulinoma cases in which low-dose (0.005-0.007 mEq/kg) calcium injection for SACST led to successful insulinoma localization. No adverse effects of SACST were observed. In conclusion, a low-dose SACST can be a favorable option as an insulinoma localization test in terms of accuracy and safety. The Japanese Society of Internal Medicine 2020-06-30 2020-10-01 /pmc/articles/PMC7644493/ /pubmed/32611954 http://dx.doi.org/10.2169/internalmedicine.4396-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hatoko, Tomonobu
Murakami, Takaaki
Sone, Masakatsu
Yabe, Daisuke
Masui, Toshihiko
Nakamoto, Yuji
Furuta, Akihiro
Uza, Norimitsu
Kodama, Yuzo
Harada, Norio
Ogura, Masahito
Yasoda, Akihiro
Inagaki, Nobuya
Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases
title Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases
title_full Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases
title_fullStr Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases
title_full_unstemmed Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases
title_short Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases
title_sort low-dose selective arterial calcium stimulation test for localizing insulinoma: a single-center experience of five consecutive cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644493/
https://www.ncbi.nlm.nih.gov/pubmed/32611954
http://dx.doi.org/10.2169/internalmedicine.4396-20
work_keys_str_mv AT hatokotomonobu lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT murakamitakaaki lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT sonemasakatsu lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT yabedaisuke lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT masuitoshihiko lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT nakamotoyuji lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT furutaakihiro lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT uzanorimitsu lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT kodamayuzo lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT haradanorio lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT oguramasahito lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT yasodaakihiro lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases
AT inagakinobuya lowdoseselectivearterialcalciumstimulationtestforlocalizinginsulinomaasinglecenterexperienceoffiveconsecutivecases

Ejemplares similares