Autologous Hematopoietic Recovery after Unrelated Umbilical Cord Blood Transplantation with Myeloablative Conditioning for Acute Myelogenous Leukemia

Autologous hematopoietic recovery after allogeneic hematopoietic cell transplantation (allo-HCT) is rare in patients who receive myeloablative conditioning (MAC). Autologous hematopoietic recovery suggests graft rejection, leading to concerns about subsequent disease relapse. We herein report a rare...

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Detalles Bibliográficos
Autores principales: Gomyo, Ayumi, Nakasone, Hideki, Wada, Hidenori, Kawamura, Shunto, Yoshino, Nozomu, Takeshita, Junko, Yoshimura, Kazuki, Misaki, Yukiko, Tanihara, Aki, Akahoshi, Yu, Kusuda, Machiko, Tamaki, Masaharu, Kawamura, Koji, Kimura, Shun-ichi, Kako, Shinichi, Kanda, Yoshinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644496/
https://www.ncbi.nlm.nih.gov/pubmed/32536652
http://dx.doi.org/10.2169/internalmedicine.4829-20
Descripción
Sumario:Autologous hematopoietic recovery after allogeneic hematopoietic cell transplantation (allo-HCT) is rare in patients who receive myeloablative conditioning (MAC). Autologous hematopoietic recovery suggests graft rejection, leading to concerns about subsequent disease relapse. We herein report a rare case of a patient with acute leukemia who experienced autologous hematopoietic recovery after cord blood transplantation (CBT) with total body irradiation-based MAC. Chromosomal abnormalities were repeatedly detected without any disease relapse for eight months. The accumulation of similar cases is required to accurately assess the incidence and clinical outcomes of autologous hematopoietic recovery after CBT with MAC.

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