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Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients

The glutamatergic system has previously been shown to be involved in the pathophysiology of schizophrenia and the mechanisms of action of antipsychotic treatment. The present study aimed to investigate the relationship between the levels of glutamate (Glu) or Glu/total creatine (Glu/Cr+PCr) in the a...

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Autores principales: Li, Jinguang, Ren, Honghong, He, Ying, Li, ZongChang, Ma, Xiaoqian, Yuan, Liu, Ouyang, Lijun, Zhou, Jun, Wang, Dong, Li, Chunwang, Chen, Xiaogang, Han, Hongying, Tang, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644538/
https://www.ncbi.nlm.nih.gov/pubmed/33192666
http://dx.doi.org/10.3389/fpsyt.2020.553269
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author Li, Jinguang
Ren, Honghong
He, Ying
Li, ZongChang
Ma, Xiaoqian
Yuan, Liu
Ouyang, Lijun
Zhou, Jun
Wang, Dong
Li, Chunwang
Chen, Xiaogang
Han, Hongying
Tang, Jinsong
author_facet Li, Jinguang
Ren, Honghong
He, Ying
Li, ZongChang
Ma, Xiaoqian
Yuan, Liu
Ouyang, Lijun
Zhou, Jun
Wang, Dong
Li, Chunwang
Chen, Xiaogang
Han, Hongying
Tang, Jinsong
author_sort Li, Jinguang
collection PubMed
description The glutamatergic system has previously been shown to be involved in the pathophysiology of schizophrenia and the mechanisms of action of antipsychotic treatment. The present study aimed to investigate the relationship between the levels of glutamate (Glu) or Glu/total creatine (Glu/Cr+PCr) in the anterior cingulate cortex (ACC) and psychiatric symptoms as well as the response to antipsychotic treatment. We performed proton magnetic resonance spectroscopy ((1)H–MRS) to measure Glu and Glu/Cr+PCr in the ACC of 35 drug-naïve first-episode schizophrenia (FES) patients and 40 well-matched healthy controls (HCs). After scanning, we treated the patients with risperidone for eight weeks. Remission status was based on the Positive and Negative Syndrome Scale (PANSS) scores at week 8. At baseline, there were no significant differences in the levels of Glu or Glu/Cr+PCr in the ACC between drug-naïve FES patients and HCs. Lower baseline levels of Glu/Cr+PCr but not Glu in the ACC were associated with more severe negative symptoms of schizophrenia. Compared to the remission group (RM), the non-remission group (NRM) had lower baseline ACC Glu levels (P < 0.05). Our results suggest that ACC Glu levels may be related to the severity of symptoms in the early stages of schizophrenia and therefore may be a marker with which to evaluate the treatment effect of antipsychotics in schizophrenia patients.
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spelling pubmed-76445382020-11-13 Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients Li, Jinguang Ren, Honghong He, Ying Li, ZongChang Ma, Xiaoqian Yuan, Liu Ouyang, Lijun Zhou, Jun Wang, Dong Li, Chunwang Chen, Xiaogang Han, Hongying Tang, Jinsong Front Psychiatry Psychiatry The glutamatergic system has previously been shown to be involved in the pathophysiology of schizophrenia and the mechanisms of action of antipsychotic treatment. The present study aimed to investigate the relationship between the levels of glutamate (Glu) or Glu/total creatine (Glu/Cr+PCr) in the anterior cingulate cortex (ACC) and psychiatric symptoms as well as the response to antipsychotic treatment. We performed proton magnetic resonance spectroscopy ((1)H–MRS) to measure Glu and Glu/Cr+PCr in the ACC of 35 drug-naïve first-episode schizophrenia (FES) patients and 40 well-matched healthy controls (HCs). After scanning, we treated the patients with risperidone for eight weeks. Remission status was based on the Positive and Negative Syndrome Scale (PANSS) scores at week 8. At baseline, there were no significant differences in the levels of Glu or Glu/Cr+PCr in the ACC between drug-naïve FES patients and HCs. Lower baseline levels of Glu/Cr+PCr but not Glu in the ACC were associated with more severe negative symptoms of schizophrenia. Compared to the remission group (RM), the non-remission group (NRM) had lower baseline ACC Glu levels (P < 0.05). Our results suggest that ACC Glu levels may be related to the severity of symptoms in the early stages of schizophrenia and therefore may be a marker with which to evaluate the treatment effect of antipsychotics in schizophrenia patients. Frontiers Media S.A. 2020-10-23 /pmc/articles/PMC7644538/ /pubmed/33192666 http://dx.doi.org/10.3389/fpsyt.2020.553269 Text en Copyright © 2020 Li, Ren, He, Li, Ma, Yuan, Ouyang, Zhou, Wang, Li, Chen, Han and Tang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Li, Jinguang
Ren, Honghong
He, Ying
Li, ZongChang
Ma, Xiaoqian
Yuan, Liu
Ouyang, Lijun
Zhou, Jun
Wang, Dong
Li, Chunwang
Chen, Xiaogang
Han, Hongying
Tang, Jinsong
Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients
title Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients
title_full Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients
title_fullStr Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients
title_full_unstemmed Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients
title_short Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients
title_sort anterior cingulate cortex glutamate levels are related to response to initial antipsychotic treatment in drug-naive first-episode schizophrenia patients
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644538/
https://www.ncbi.nlm.nih.gov/pubmed/33192666
http://dx.doi.org/10.3389/fpsyt.2020.553269
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