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Mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: Cases series

BACKGROUND: Mycobacterium abscessus is one of the most pathogenic and drug-resistant opportunistic microorganisms among the nontuberculous mycobacteria (NTM) involved in skin and soft tissue infections (SSTI) associated with cosmetic surgical procedures. However, NTM infection is often wrongly diagn...

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Autores principales: Moreno-Izquierdo, C., Zurita, J., Contreras-Yametti, F.I., Jara-Palacios, M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644577/
https://www.ncbi.nlm.nih.gov/pubmed/33194548
http://dx.doi.org/10.1016/j.idcr.2020.e00992
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author Moreno-Izquierdo, C.
Zurita, J.
Contreras-Yametti, F.I.
Jara-Palacios, M.A.
author_facet Moreno-Izquierdo, C.
Zurita, J.
Contreras-Yametti, F.I.
Jara-Palacios, M.A.
author_sort Moreno-Izquierdo, C.
collection PubMed
description BACKGROUND: Mycobacterium abscessus is one of the most pathogenic and drug-resistant opportunistic microorganisms among the nontuberculous mycobacteria (NTM) involved in skin and soft tissue infections (SSTI) associated with cosmetic surgical procedures. However, NTM infection is often wrongly diagnosed initially causing prolonged suffering. Here is described the author’s experience working with patients who developed M. abscessus SSTI after cosmetic procedures. METHODS: Patients who developed NTM infection after undergoing cosmetic procedures, and who presented at the Hospital Metropolitano and Hospital Vozandes (Quito, Ecuador) between 2013–2016. A review of patient medical records was performed. RESULTS: Five patients with culture proven M. abscessus subspecies abscessus SSTI after cosmetic surgeries were identified. All patients were treated with aggressive surgical debridement and antibiotics. CONCLUSIONS: A rapidly spreading wound infection presenting two or more weeks after a cosmetic procedure that fails to respond to standard antimicrobial therapy should raise suspicion for NTM infection. Samples for acid-fast bacilli smear, cultures, and PCR from infected tissue should be taken. Surgical drainage and debridement are recommended along with a long course of antibiotics. In the absence of clinical trials, a combination of amikacin, imipenem, and clarithromycin may be an adequate initial treatment for M. abscessus subspecies abscessus SSTI in immunocompetent patients.
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spelling pubmed-76445772020-11-13 Mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: Cases series Moreno-Izquierdo, C. Zurita, J. Contreras-Yametti, F.I. Jara-Palacios, M.A. IDCases Article BACKGROUND: Mycobacterium abscessus is one of the most pathogenic and drug-resistant opportunistic microorganisms among the nontuberculous mycobacteria (NTM) involved in skin and soft tissue infections (SSTI) associated with cosmetic surgical procedures. However, NTM infection is often wrongly diagnosed initially causing prolonged suffering. Here is described the author’s experience working with patients who developed M. abscessus SSTI after cosmetic procedures. METHODS: Patients who developed NTM infection after undergoing cosmetic procedures, and who presented at the Hospital Metropolitano and Hospital Vozandes (Quito, Ecuador) between 2013–2016. A review of patient medical records was performed. RESULTS: Five patients with culture proven M. abscessus subspecies abscessus SSTI after cosmetic surgeries were identified. All patients were treated with aggressive surgical debridement and antibiotics. CONCLUSIONS: A rapidly spreading wound infection presenting two or more weeks after a cosmetic procedure that fails to respond to standard antimicrobial therapy should raise suspicion for NTM infection. Samples for acid-fast bacilli smear, cultures, and PCR from infected tissue should be taken. Surgical drainage and debridement are recommended along with a long course of antibiotics. In the absence of clinical trials, a combination of amikacin, imipenem, and clarithromycin may be an adequate initial treatment for M. abscessus subspecies abscessus SSTI in immunocompetent patients. Elsevier 2020-10-25 /pmc/articles/PMC7644577/ /pubmed/33194548 http://dx.doi.org/10.1016/j.idcr.2020.e00992 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Moreno-Izquierdo, C.
Zurita, J.
Contreras-Yametti, F.I.
Jara-Palacios, M.A.
Mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: Cases series
title Mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: Cases series
title_full Mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: Cases series
title_fullStr Mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: Cases series
title_full_unstemmed Mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: Cases series
title_short Mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: Cases series
title_sort mycobacterium abscessus subspecies abscessus infection associated with cosmetic surgical procedures: cases series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644577/
https://www.ncbi.nlm.nih.gov/pubmed/33194548
http://dx.doi.org/10.1016/j.idcr.2020.e00992
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