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Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

A major feature of amyotrophic lateral sclerosis (ALS) pathology is the accumulation of ubiquitin (Ub) into intracellular inclusions. This sequestration of Ub may reduce the availability of free Ub, disrupting Ub homeostasis and ultimately compromising cellular function and survival. We previously r...

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Detalles Bibliográficos
Autores principales:	Farrawell, Natalie E., McAlary, Luke, Lum, Jeremy S., Chisholm, Christen G., Warraich, Sadaf T., Blair, Ian P., Vine, Kara L., Saunders, Darren N., Yerbury, Justin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644588/ https://www.ncbi.nlm.nih.gov/pubmed/33196025 http://dx.doi.org/10.1016/j.isci.2020.101700

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