Activation of EPHA2-ROBO1 Heterodimer by SLIT2 Attenuates Non-canonical Signaling and Proliferation in Squamous Cell Carcinomas

The tyrosine kinase receptor ephrin receptor A2 (EPHA2) is overexpressed in lung (LSCC) and head and neck (HNSCC) squamous cell carcinomas. Although EPHA2 can inhibit tumorigenesis in a ligand-dependent fashion via phosphorylation of Y588 and Y772, it can promote tumorigenesis in a ligand-independen...

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Detalles Bibliográficos
Autores principales: Srivastava, Saumya, Pang, Ka Ming, Iida, Mari, Nelson, Michael S., Liu, Jiayi, Nam, Arin, Wang, Jiale, Mambetsariev, Isa, Pillai, Raju, Mohanty, Atish, McDaniel, Nellie, Behal, Amita, Kulkarni, Prakash, Wheeler, Deric L., Salgia, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644594/
https://www.ncbi.nlm.nih.gov/pubmed/33196021
http://dx.doi.org/10.1016/j.isci.2020.101692

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