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Alcohol induces TGFβ1 via downregulation of miR-1946a in murine lung fibroblast

Exaggerated transforming growth factor-beta 1 (TGFβ1) expression worsens fibroproliferation following bleomycin-induced lung injury in alcohol-fed mice. MicroRNA (miR)-1946a is predicted to bind to the TGFβ1 3′ untranslated region (UTR), thereby inhibiting its transcription. We hypothesize that alco...

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Detalles Bibliográficos
Autores principales:	Fan, Xian, Mills, Stephen T., Kaalla, Mevelyn J., Sueblinvong, Viranuj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644620/ https://www.ncbi.nlm.nih.gov/pubmed/33154445 http://dx.doi.org/10.1038/s41598-020-76148-5

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