ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

The underlying pathological mechanisms of glaucomatous trabecular meshwork (TM) damage and elevation of intraocular pressure (IOP) are poorly understood. Here, we report that the chronic endoplasmic reticulum (ER) stress-induced ATF4-CHOP-GADD34 pathway is activated in TM of human and mouse glaucoma...

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Detalles Bibliográficos
Autores principales: Kasetti, Ramesh B., Patel, Pinkal D., Maddineni, Prabhavathi, Patil, Shruti, Kiehlbauch, Charles, Millar, J. Cameron, Searby, Charles C., Raghunathan, VijayKrishna, Sheffield, Val C., Zode, Gulab S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644693/
https://www.ncbi.nlm.nih.gov/pubmed/33154371
http://dx.doi.org/10.1038/s41467-020-19352-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644693/
https://www.ncbi.nlm.nih.gov/pubmed/33154371
http://dx.doi.org/10.1038/s41467-020-19352-1

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