Cargando…

ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

The underlying pathological mechanisms of glaucomatous trabecular meshwork (TM) damage and elevation of intraocular pressure (IOP) are poorly understood. Here, we report that the chronic endoplasmic reticulum (ER) stress-induced ATF4-CHOP-GADD34 pathway is activated in TM of human and mouse glaucoma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kasetti, Ramesh B., Patel, Pinkal D., Maddineni, Prabhavathi, Patil, Shruti, Kiehlbauch, Charles, Millar, J. Cameron, Searby, Charles C., Raghunathan, VijayKrishna, Sheffield, Val C., Zode, Gulab S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644693/ https://www.ncbi.nlm.nih.gov/pubmed/33154371 http://dx.doi.org/10.1038/s41467-020-19352-1

Ejemplares similares

Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin
por: Kasetti, Ramesh B., et al.
Publicado: (2021)

CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma
por: Maddineni, Prabhavathi, et al.
Publicado: (2020)

Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork
por: Kasetti, Ramesh B., et al.
Publicado: (2020)

Correction: Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork
por: Kasetti, Ramesh B., et al.
Publicado: (2020)

Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork
por: Kasetti, Ramesh B., et al.
Publicado: (2017)

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma
por: Patel, Pinkal D., et al.
Publicado: (2021)

Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9
por: Maddineni, Prabhavathi, et al.
Publicado: (2021)

A Novel Mouse Model of TGFβ2-Induced Ocular Hypertension Using Lentiviral Gene Delivery
por: Patil, Shruti V., et al.
Publicado: (2022)

Technical brief: Direct, real-time electrochemical measurement of nitric oxide in ex vivo cultured human corneoscleral segments
por: Patel, Pinkal D., et al.
Publicado: (2020)

Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork
por: Kasetti, Ramesh B., et al.
Publicado: (2016)

Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFβ2 Induced Primary Open Angle Glaucoma
por: Kasetti, Ramesh B., et al.
Publicado: (2021)

The Centriolar Satellite Protein AZI1 Interacts with BBS4 and Regulates Ciliary Trafficking of the BBSome
por: Chamling, Xitiz, et al.
Publicado: (2014)

Zika Virus Infects Trabecular Meshwork and Causes Trabeculitis and Glaucomatous Pathology in Mouse Eyes
por: Singh, Pawan Kumar, et al.
Publicado: (2019)

A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened
por: Seo, Seongjin, et al.
Publicado: (2011)

Enhanced Orai1-mediated store-operated Ca(2+) channel/calpain signaling contributes to high glucose-induced podocyte injury
por: Tao, Yu, et al.
Publicado: (2022)

Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein
por: Scott, Charles Anthony, et al.
Publicado: (2017)

Comparison of whole blood and PBMC assays for T-cell functional analysis
por: Deenadayalan, Anbarasu, et al.
Publicado: (2013)

The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6
por: Sung, Shu-Chiun, et al.
Publicado: (2009)

The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts
por: Stauffer, Winston T., et al.
Publicado: (2020)

ER Stress Activates the TOR Pathway through Atf6
por: Allen, Dylan, et al.
Publicado: (2018)

Transforming growth factor-β2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway
por: Zode, Gulab S., et al.
Publicado: (2011)

A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture
por: Zadoo, Serena, et al.
Publicado: (2016)

DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress
por: Yang, Jungwoo, et al.
Publicado: (2019)

Ectopic Expression of Human BBS4 Can Rescue Bardet-Biedl Syndrome Phenotypes in Bbs4 Null Mice
por: Chamling, Xitiz, et al.
Publicado: (2013)

Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis
por: Burkewitz, Kristopher, et al.
Publicado: (2020)

A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability
por: Jheng, Jia-Rong, et al.
Publicado: (2018)

Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
por: Nguyen, Duy, et al.
Publicado: (2018)

Quantitative Mass Spectrometry Characterizes Client Spectra of Components for Targeting of Membrane Proteins to and Their Insertion into the Membrane of the Human ER
por: Jung, Martin, et al.
Publicado: (2023)

The Electrocardiogram of an ER Patient With Chest Pain
por: Panneerselvam, Arunkumar, et al.
Publicado: (2011)

Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress
por: Gallagher, Ciara M, et al.
Publicado: (2016)

The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma
por: Dadey, David Y.A., et al.
Publicado: (2015)

Transmission of ER stress response by ATF6 promotes endochondral bone growth
por: Xiong, Zhangyuan, et al.
Publicado: (2015)

Lysophosphatidic Acid and IL-6 Trans-signaling Interact via YAP/TAZ and STAT3 Signaling Pathways in Human Trabecular Meshwork Cells
por: Yemanyi, Felix, et al.
Publicado: (2020)

Ectopic expression of BBS1 rescues male infertility, but not retinal degeneration, in a BBS1 mouse model
por: Cring, Matthew R., et al.
Publicado: (2022)

Coupled ER to Golgi Transport Reconstituted with Purified Cytosolic Proteins
por: Barlowe, Charles
Publicado: (1997)

Late Embryogenesis Abundant Protein–Client Protein Interactions
por: Dirk, Lynnette M. A., et al.
Publicado: (2020)

Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors
por: Ibe, Nnejiuwa U, et al.
Publicado: (2021)

Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response
por: Hiramatsu, Nobuhiko, et al.
Publicado: (2014)

Molecular pathway of near-infrared laser phototoxicity involves ATF-4 orchestrated ER stress
por: Khan, Imran, et al.
Publicado: (2015)

PERK/ATF3-Reduced ER Stress on high potassium environment in the suppression of tumor ferroptosis
por: Pu, Xufeng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_is1ibn70d01peuon3u8ap6oi71