3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro

Heparan sulfate (HS) chains, covalently linked to heparan sulfate proteoglycans (HSPG), promote synaptic development and functions by connecting various synaptic adhesion proteins (AP). HS binding to AP could vary according to modifications of HS chains by different sulfotransferases. 3-O-sulfotrans...

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Detalles Bibliográficos
Autores principales: Maïza, Auriane, Sidahmed-Adrar, Nazha, Michel, Patrick P., Carpentier, Gilles, Habert, Damien, Dalle, Carine, Redouane, Walid, Hamza, Magda, van Kuppevelt, TH, Ouidja, Mohand Ouidir, Courty, José, Chantepie, Sandrine, Papy-Garcia, Dulce, Stettler, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644699/
https://www.ncbi.nlm.nih.gov/pubmed/33154448
http://dx.doi.org/10.1038/s41598-020-76030-4

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