A circular RNA generated from an intron of the insulin gene controls insulin secretion

Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing the lariat sequence of the second intron of the insulin gene. Silencing of this intronic circular RNA in pancrea...

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Detalles Bibliográficos
Autores principales: Stoll, Lisa, Rodríguez-Trejo, Adriana, Guay, Claudiane, Brozzi, Flora, Bayazit, Mustafa Bilal, Gattesco, Sonia, Menoud, Véronique, Sobel, Jonathan, Marques, Ana Claudia, Venø, Morten Trillingsgaard, Esguerra, Jonathan Lou S., Barghouth, Mohammad, Suleiman, Mara, Marselli, Lorella, Kjems, Jørgen, Eliasson, Lena, Renström, Erik, Bouzakri, Karim, Pinget, Michel, Marchetti, Piero, Regazzi, Romano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644714/
https://www.ncbi.nlm.nih.gov/pubmed/33154349
http://dx.doi.org/10.1038/s41467-020-19381-w

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