Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis

PAX5 is one of the most frequently mutated genes in B-cell acute lymphoblastic leukemia (B-ALL), and children with inherited preleukemic PAX5 mutations are at a higher risk of developing the disease. Abnormal profiles of inflammatory markers have been detected in neonatal blood spot samples of child...

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Detalles Bibliográficos
Autores principales: Isidro-Hernández, Marta, Mayado, Andrea, Casado-García, Ana, Martínez-Cano, Jorge, Palmi, Chiara, Fazio, Grazia, Orfao, Alberto, Ribera, Jordi, Ribera, Josep Maria, Zamora, Lurdes, Raboso-Gallego, Javier, Blanco, Oscar, Alonso-López, Diego, De Las Rivas, Javier, Jiménez, Rafael, García Criado, Francisco Javier, García Cenador, María Begoña, Ramírez-Orellana, Manuel, Cazzaniga, Giovanni, Cobaleda, César, Vicente-Dueñas, Carolina, Sánchez-García, Isidro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644722/
https://www.ncbi.nlm.nih.gov/pubmed/33154497
http://dx.doi.org/10.1038/s41598-020-76206-y

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