Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting

Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets. The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level, which play a key role in carcinogenesis. Therefore, to impro...

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Autores principales: Fu, Xianglei, Shi, Yanbin, Qi, Tongtong, Qiu, Shengnan, Huang, Yi, Zhao, Xiaogang, Sun, Qifeng, Lin, Guimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644763/
https://www.ncbi.nlm.nih.gov/pubmed/33154350
http://dx.doi.org/10.1038/s41392-020-00342-0
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author Fu, Xianglei
Shi, Yanbin
Qi, Tongtong
Qiu, Shengnan
Huang, Yi
Zhao, Xiaogang
Sun, Qifeng
Lin, Guimei
author_facet Fu, Xianglei
Shi, Yanbin
Qi, Tongtong
Qiu, Shengnan
Huang, Yi
Zhao, Xiaogang
Sun, Qifeng
Lin, Guimei
author_sort Fu, Xianglei
collection PubMed
description Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets. The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level, which play a key role in carcinogenesis. Therefore, to improve the therapeutic efficiency of drugs, researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures. In this review, we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations, aiming at providing guidance in the overall design of precise nanomedicine. Additionally, future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine.
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spelling pubmed-76447632020-11-06 Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting Fu, Xianglei Shi, Yanbin Qi, Tongtong Qiu, Shengnan Huang, Yi Zhao, Xiaogang Sun, Qifeng Lin, Guimei Signal Transduct Target Ther Review Article Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets. The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level, which play a key role in carcinogenesis. Therefore, to improve the therapeutic efficiency of drugs, researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures. In this review, we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations, aiming at providing guidance in the overall design of precise nanomedicine. Additionally, future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine. Nature Publishing Group UK 2020-11-06 /pmc/articles/PMC7644763/ /pubmed/33154350 http://dx.doi.org/10.1038/s41392-020-00342-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Fu, Xianglei
Shi, Yanbin
Qi, Tongtong
Qiu, Shengnan
Huang, Yi
Zhao, Xiaogang
Sun, Qifeng
Lin, Guimei
Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting
title Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting
title_full Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting
title_fullStr Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting
title_full_unstemmed Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting
title_short Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting
title_sort precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644763/
https://www.ncbi.nlm.nih.gov/pubmed/33154350
http://dx.doi.org/10.1038/s41392-020-00342-0
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