L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells

The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher inhibitory activity than the synthesized and...

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Detalles Bibliográficos
Autores principales: Stovbun, S.V., Vedenkin, A.S., Bukhvostov, A.A., Koroleva, L.S., Silnikov, V.N., Kuznetsov, D.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644855/
https://www.ncbi.nlm.nih.gov/pubmed/33195826
http://dx.doi.org/10.1016/j.bbrep.2020.100835
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author Stovbun, S.V.
Vedenkin, A.S.
Bukhvostov, A.A.
Koroleva, L.S.
Silnikov, V.N.
Kuznetsov, D.A.
author_facet Stovbun, S.V.
Vedenkin, A.S.
Bukhvostov, A.A.
Koroleva, L.S.
Silnikov, V.N.
Kuznetsov, D.A.
author_sort Stovbun, S.V.
collection PubMed
description The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher inhibitory activity than the synthesized and isolated D enantiomers of polynucleotides. The work also proposes a biophysical model that describes this effect.
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spelling pubmed-76448552020-11-13 L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells Stovbun, S.V. Vedenkin, A.S. Bukhvostov, A.A. Koroleva, L.S. Silnikov, V.N. Kuznetsov, D.A. Biochem Biophys Rep Research Article The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher inhibitory activity than the synthesized and isolated D enantiomers of polynucleotides. The work also proposes a biophysical model that describes this effect. Elsevier 2020-11-02 /pmc/articles/PMC7644855/ /pubmed/33195826 http://dx.doi.org/10.1016/j.bbrep.2020.100835 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Stovbun, S.V.
Vedenkin, A.S.
Bukhvostov, A.A.
Koroleva, L.S.
Silnikov, V.N.
Kuznetsov, D.A.
L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells
title L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells
title_full L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells
title_fullStr L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells
title_full_unstemmed L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells
title_short L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells
title_sort l, d-polydeoxyribonucleotides to provide an essential inhibitory effect on dna polymerase β of human myeloid leukemia hl60 cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644855/
https://www.ncbi.nlm.nih.gov/pubmed/33195826
http://dx.doi.org/10.1016/j.bbrep.2020.100835
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