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The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review

BACKGROUND: Bone imbalance between anabolic and catabolic processes at the level of remodeling unit due to the prevalence of resorbing activity, represents a health problem of aging. The consequence is the negative balance of bone turnover that can lead to osteoporosis. Physical activity (PA) can pl...

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Autores principales: Marini, Sofia, Barone, Giuseppe, Masini, Alice, Dallolio, Laura, Bragonzoni, Laura, Longobucco, Yari, Maffei, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644859/
https://www.ncbi.nlm.nih.gov/pubmed/33193098
http://dx.doi.org/10.3389/fendo.2020.585689
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author Marini, Sofia
Barone, Giuseppe
Masini, Alice
Dallolio, Laura
Bragonzoni, Laura
Longobucco, Yari
Maffei, Francesca
author_facet Marini, Sofia
Barone, Giuseppe
Masini, Alice
Dallolio, Laura
Bragonzoni, Laura
Longobucco, Yari
Maffei, Francesca
author_sort Marini, Sofia
collection PubMed
description BACKGROUND: Bone imbalance between anabolic and catabolic processes at the level of remodeling unit due to the prevalence of resorbing activity, represents a health problem of aging. The consequence is the negative balance of bone turnover that can lead to osteoporosis. Physical activity (PA) can play a central role in the comprehensive management of osteoporosis, since it induces the anabolism of bone tissue. Bone turnover biomarkers, reflecting the cellular activity linked to bone metabolism, can represent an evaluation tool to assess the efficacy of PA in the osteoporotic population. The aim of this systematic review, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, was to investigate the effects of PA interventions on bone biomarkers in people with osteoporosis. METHODS: A comprehensive literature search of electronic databases was conducted through PubMed, Cochrane, Cinahl, Embase, Trip, to find randomized controlled trials (RCTs) investigating the topic of PA and bone turnover biomarkers in the osteoporosis population. In accordance with the Cochrane risk-of-bias tool, the quality of each study was assessed. RESULTS: Out of 992 identified articles, 136 full texts were screened. Only three RTCs matched the eligibility criteria. In one study, sub-maximal aerobic exercise improved Bone-specific alkaline phosphatase (bone formation biomarker) and Amino-terminal Crosslinked Telopeptide of type 1 collagen (bone resorption biomarker) in osteoporotic women. The other two studies showed a positive effect on total alkaline phosphatase (a non-specific bone formation biomarker) in women with osteoporosis. CONCLUSION: The systematic review revealed possible exercise benefits in terms of improving bone formation and decreasing bone resorption biomarkers in the osteoporotic population. However, these results should be interpreted with caution, especially due to the limited number and poor quality of the studies included. Further research is needed to estimate the influence of PA on bone biomarkers in the osteoporosis management.
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spelling pubmed-76448592020-11-13 The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review Marini, Sofia Barone, Giuseppe Masini, Alice Dallolio, Laura Bragonzoni, Laura Longobucco, Yari Maffei, Francesca Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Bone imbalance between anabolic and catabolic processes at the level of remodeling unit due to the prevalence of resorbing activity, represents a health problem of aging. The consequence is the negative balance of bone turnover that can lead to osteoporosis. Physical activity (PA) can play a central role in the comprehensive management of osteoporosis, since it induces the anabolism of bone tissue. Bone turnover biomarkers, reflecting the cellular activity linked to bone metabolism, can represent an evaluation tool to assess the efficacy of PA in the osteoporotic population. The aim of this systematic review, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, was to investigate the effects of PA interventions on bone biomarkers in people with osteoporosis. METHODS: A comprehensive literature search of electronic databases was conducted through PubMed, Cochrane, Cinahl, Embase, Trip, to find randomized controlled trials (RCTs) investigating the topic of PA and bone turnover biomarkers in the osteoporosis population. In accordance with the Cochrane risk-of-bias tool, the quality of each study was assessed. RESULTS: Out of 992 identified articles, 136 full texts were screened. Only three RTCs matched the eligibility criteria. In one study, sub-maximal aerobic exercise improved Bone-specific alkaline phosphatase (bone formation biomarker) and Amino-terminal Crosslinked Telopeptide of type 1 collagen (bone resorption biomarker) in osteoporotic women. The other two studies showed a positive effect on total alkaline phosphatase (a non-specific bone formation biomarker) in women with osteoporosis. CONCLUSION: The systematic review revealed possible exercise benefits in terms of improving bone formation and decreasing bone resorption biomarkers in the osteoporotic population. However, these results should be interpreted with caution, especially due to the limited number and poor quality of the studies included. Further research is needed to estimate the influence of PA on bone biomarkers in the osteoporosis management. Frontiers Media S.A. 2020-10-23 /pmc/articles/PMC7644859/ /pubmed/33193098 http://dx.doi.org/10.3389/fendo.2020.585689 Text en Copyright © 2020 Marini, Barone, Masini, Dallolio, Bragonzoni, Longobucco and Maffei http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Marini, Sofia
Barone, Giuseppe
Masini, Alice
Dallolio, Laura
Bragonzoni, Laura
Longobucco, Yari
Maffei, Francesca
The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review
title The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review
title_full The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review
title_fullStr The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review
title_full_unstemmed The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review
title_short The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review
title_sort effect of physical activity on bone biomarkers in people with osteoporosis: a systematic review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644859/
https://www.ncbi.nlm.nih.gov/pubmed/33193098
http://dx.doi.org/10.3389/fendo.2020.585689
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