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Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion
Precision medicine has been getting more attention in lung cancer treatment. Here, we report an unusual case of a 71-year-old Chinese male patient with poorly differentiated lung adenocarcinoma with lymph node metastasis. A 5 years' treatment history of this patient is reported. By serial genet...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645070/ https://www.ncbi.nlm.nih.gov/pubmed/33194628 http://dx.doi.org/10.3389/fonc.2020.561341 |
| _version_ | 1783606589249290240 |
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| author | Miao, Zhihua Mu, Tianhao Liu, Longying Rao, Jingjie Jin, Min Wang, Zhizheng Wang, Hui Lu, Chao Gong, Xiaolin Zheng, Dongcai Zheng, Daoming Li, Xin Li, Yingmei Chen, Shifu Shu, Xinhua |
| author_facet | Miao, Zhihua Mu, Tianhao Liu, Longying Rao, Jingjie Jin, Min Wang, Zhizheng Wang, Hui Lu, Chao Gong, Xiaolin Zheng, Dongcai Zheng, Daoming Li, Xin Li, Yingmei Chen, Shifu Shu, Xinhua |
| author_sort | Miao, Zhihua |
| collection | PubMed |
| description | Precision medicine has been getting more attention in lung cancer treatment. Here, we report an unusual case of a 71-year-old Chinese male patient with poorly differentiated lung adenocarcinoma with lymph node metastasis. A 5 years' treatment history of this patient is reported. By serial genetic tests of circulating tumor DNA (ctDNA) from peripheral blood and sediment cell genomic DNA (PE-sDNA) from pleural effusion, a novel chronological combination treatment of icotinib, osimertinib, and crizotinib was adopted for the present genetic mutations, including EGFR exon 19 deletion, EGFR p.T790M, and MET amplification. |
| format | Online Article Text |
| id | pubmed-7645070 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-76450702020-11-13 Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion Miao, Zhihua Mu, Tianhao Liu, Longying Rao, Jingjie Jin, Min Wang, Zhizheng Wang, Hui Lu, Chao Gong, Xiaolin Zheng, Dongcai Zheng, Daoming Li, Xin Li, Yingmei Chen, Shifu Shu, Xinhua Front Oncol Oncology Precision medicine has been getting more attention in lung cancer treatment. Here, we report an unusual case of a 71-year-old Chinese male patient with poorly differentiated lung adenocarcinoma with lymph node metastasis. A 5 years' treatment history of this patient is reported. By serial genetic tests of circulating tumor DNA (ctDNA) from peripheral blood and sediment cell genomic DNA (PE-sDNA) from pleural effusion, a novel chronological combination treatment of icotinib, osimertinib, and crizotinib was adopted for the present genetic mutations, including EGFR exon 19 deletion, EGFR p.T790M, and MET amplification. Frontiers Media S.A. 2020-10-23 /pmc/articles/PMC7645070/ /pubmed/33194628 http://dx.doi.org/10.3389/fonc.2020.561341 Text en Copyright © 2020 Miao, Mu, Liu, Rao, Jin, Wang, Wang, Lu, Gong, Zheng, Zheng, Li, Li, Chen and Shu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Oncology Miao, Zhihua Mu, Tianhao Liu, Longying Rao, Jingjie Jin, Min Wang, Zhizheng Wang, Hui Lu, Chao Gong, Xiaolin Zheng, Dongcai Zheng, Daoming Li, Xin Li, Yingmei Chen, Shifu Shu, Xinhua Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion |
| title | Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion |
| title_full | Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion |
| title_fullStr | Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion |
| title_full_unstemmed | Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion |
| title_short | Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion |
| title_sort | case report: a chronological combination treatment of icotinib, osimertinib, and crizotinib on lung adenocarcinoma guided by serial genetic tests of circulating tumor dna and sediment cell genomic dna from pleural effusion |
| topic | Oncology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645070/ https://www.ncbi.nlm.nih.gov/pubmed/33194628 http://dx.doi.org/10.3389/fonc.2020.561341 |
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