Recombinant Pyrin Domain Protein Attenuates Airway Inflammation and Alleviates Epithelial-Mesenchymal Transition by Inhibiting Crosstalk Between TGFβ1 and Notch1 Signaling in Chronic Asthmatic Mice

This article aims to investigate the effects of recombinant pyrin domain (RPYD) on airway inflammation and remodeling in mice with chronic asthma. The chronic asthma BALB/c mouse model was first sensitized by ovalbumin (OVA) and then challenged by OVA nebulization. RPYD or dexamethasone was given be...

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Detalles Bibliográficos
Autores principales: Wang, Zhiguang, Li, Liangchang, Wang, Chongyang, Piao, Yihua, Jiang, Jingzhi, Li, Li, Yan, Guanghai, Piao, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645102/
https://www.ncbi.nlm.nih.gov/pubmed/33192556
http://dx.doi.org/10.3389/fphys.2020.559470

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