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FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis

Purpose: To characterize the role of fibrous sheath interacting protein 2 (FSIP2) in the survival outcomes and prognosis of clear cell renal cell carcinoma (ccRCC) patients, which is currently not well understood. Methods: The Oncomine and CCLE databases were used to investigate the differential exp...

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Autores principales: Zhang, Yixiao, Zhu, Xudong, Qiao, Xinbo, Sun, Lisha, Tian, Ye, Yang, Yongliang, Zhao, Yuhong, Liu, Caigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645329/
https://www.ncbi.nlm.nih.gov/pubmed/33162809
http://dx.doi.org/10.7150/ijms.48971
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author Zhang, Yixiao
Zhu, Xudong
Qiao, Xinbo
Sun, Lisha
Tian, Ye
Yang, Yongliang
Zhao, Yuhong
Liu, Caigang
author_facet Zhang, Yixiao
Zhu, Xudong
Qiao, Xinbo
Sun, Lisha
Tian, Ye
Yang, Yongliang
Zhao, Yuhong
Liu, Caigang
author_sort Zhang, Yixiao
collection PubMed
description Purpose: To characterize the role of fibrous sheath interacting protein 2 (FSIP2) in the survival outcomes and prognosis of clear cell renal cell carcinoma (ccRCC) patients, which is currently not well understood. Methods: The Oncomine and CCLE databases were used to investigate the differential expression of FSIP2 in ccRCC versus other cancer types. Levels of FSIP2 in 85 ccRCC patients were assessed by immunohistochemical analysis; clinicopathological features related to FSIP2 expression were examined in these patients finally, disease-free survival and overall survival were estimated by survival analysis to elucidate the impact of FSIP2 expression in ccRCC patients. Results: Analysis using the Oncomine database revealed significant upregulation of the FSIP2 gene in papillary RCC, compared to that in normal tissues. Additionally, FSIP2 expression was found to be significantly associated with abnormal platelet count, positive distant metastasis, and death as the incidence of distant metastasis and death were higher in patients with FSIP2 expression compared to those without FSIP2 expression. Survival analysis revealed that FSIP2 expression was significantly related to shorter disease-free survival and overall survival. Meanwhile, patients with FSIP2 expression had worse prognosis than those without FSIP2 expression. Conclusions: FSIP2 expression is associated with poor survival outcomes and poor prognosis in ccRCC patients. FSIP2 may therefore serve as a potential predictive biomarker of ccRCC prognosis.
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spelling pubmed-76453292020-11-06 FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis Zhang, Yixiao Zhu, Xudong Qiao, Xinbo Sun, Lisha Tian, Ye Yang, Yongliang Zhao, Yuhong Liu, Caigang Int J Med Sci Research Paper Purpose: To characterize the role of fibrous sheath interacting protein 2 (FSIP2) in the survival outcomes and prognosis of clear cell renal cell carcinoma (ccRCC) patients, which is currently not well understood. Methods: The Oncomine and CCLE databases were used to investigate the differential expression of FSIP2 in ccRCC versus other cancer types. Levels of FSIP2 in 85 ccRCC patients were assessed by immunohistochemical analysis; clinicopathological features related to FSIP2 expression were examined in these patients finally, disease-free survival and overall survival were estimated by survival analysis to elucidate the impact of FSIP2 expression in ccRCC patients. Results: Analysis using the Oncomine database revealed significant upregulation of the FSIP2 gene in papillary RCC, compared to that in normal tissues. Additionally, FSIP2 expression was found to be significantly associated with abnormal platelet count, positive distant metastasis, and death as the incidence of distant metastasis and death were higher in patients with FSIP2 expression compared to those without FSIP2 expression. Survival analysis revealed that FSIP2 expression was significantly related to shorter disease-free survival and overall survival. Meanwhile, patients with FSIP2 expression had worse prognosis than those without FSIP2 expression. Conclusions: FSIP2 expression is associated with poor survival outcomes and poor prognosis in ccRCC patients. FSIP2 may therefore serve as a potential predictive biomarker of ccRCC prognosis. Ivyspring International Publisher 2020-10-08 /pmc/articles/PMC7645329/ /pubmed/33162809 http://dx.doi.org/10.7150/ijms.48971 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Zhang, Yixiao
Zhu, Xudong
Qiao, Xinbo
Sun, Lisha
Tian, Ye
Yang, Yongliang
Zhao, Yuhong
Liu, Caigang
FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis
title FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis
title_full FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis
title_fullStr FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis
title_full_unstemmed FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis
title_short FSIP2 can serve as a predictive biomarker for Clear Cell Renal Cell Carcinoma prognosis
title_sort fsip2 can serve as a predictive biomarker for clear cell renal cell carcinoma prognosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645329/
https://www.ncbi.nlm.nih.gov/pubmed/33162809
http://dx.doi.org/10.7150/ijms.48971
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