Hypobaric hypoxia preconditioning protects against hypothalamic neuron apoptosis in heat-exposed rats by reversing hypothalamic overexpression of matrix metalloproteinase-9 and ischemia

Background: Hypoxia-inducible factor-1α (HIF-1α), heat shock protein-72 (HSP-72), hemeoxygenase-1 (HO-1), and matrix metalloproteinase-9 (MMP-9) have been identified as potential therapeutic targets in the brain for cerebral ischemia. To elucidate their underlying mechanisms, we first aimed to ascer...

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Detalles Bibliográficos
Autores principales: Chao, Chien-Ming, Chen, Chun-Liang, Niu, Ko-Chi, Lin, Cheng-Hsien, Tang, Ling-Yu, Lin, Lieh-Sheng, Chang, Ching-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645337/
https://www.ncbi.nlm.nih.gov/pubmed/33162790
http://dx.doi.org/10.7150/ijms.47560

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