Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin (SM), neurodegeneration, and early death. Here, we describe the downregulation of the endocannabinoid (eCB) system in neurons of ASM knockout (ASM‐KO) mice and a ASMD patient. High SM reduced expression of the eC...

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Detalles Bibliográficos
Autores principales: Bartoll, Adrián, Toledano‐Zaragoza, Ana, Casas, Josefina, Guzmán, Manuel, Schuchman, Edward H, Ledesma, María Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645369/
https://www.ncbi.nlm.nih.gov/pubmed/33016621
http://dx.doi.org/10.15252/emmm.201911776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645369/
https://www.ncbi.nlm.nih.gov/pubmed/33016621
http://dx.doi.org/10.15252/emmm.201911776

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