microRNA-221 Inhibits Latent TGF-β1 Activation through Targeting Thrombospondin-1 to Attenuate Kidney Failure-Induced Cardiac Fibrosis

Kidney failure (KF) is associated with cardiac fibrosis and significantly increased mortality in heart failure. Thrombospondin-1 (TSP1), a key regulator of latent transforming growth factor-β1 (L-TGF-β1) activation, is a predicted target of miR-221. We hypothesized miR-221 attenuates severe KF-assoc...

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Detalles Bibliográficos
Autores principales: Zhou, Yue, Ng, Denise Yu En, Richards, Arthur Mark, Wang, Peipei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645417/
https://www.ncbi.nlm.nih.gov/pubmed/33230477
http://dx.doi.org/10.1016/j.omtn.2020.09.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645417/
https://www.ncbi.nlm.nih.gov/pubmed/33230477
http://dx.doi.org/10.1016/j.omtn.2020.09.041

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