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Impact of concurrent diabetes on periodontal health in patients with acromegaly
Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytok...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645583/ https://www.ncbi.nlm.nih.gov/pubmed/33154456 http://dx.doi.org/10.1038/s41598-020-76067-5 |
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author | Jain, Akanksha Gupta, Shipra Bhansali, Anil Gupta, Mili Jain, Ashish Bhaskar, Nandini Kaur, Rose Kanwaljeet |
author_facet | Jain, Akanksha Gupta, Shipra Bhansali, Anil Gupta, Mili Jain, Ashish Bhaskar, Nandini Kaur, Rose Kanwaljeet |
author_sort | Jain, Akanksha |
collection | PubMed |
description | Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytokines status in treatment-naive active acromegaly patients with and without diabetes. Eleven patients, each of acromegaly with and without diabetes and 20 healthy controls were enrolled. Periodontal parameters were assessed. GCF and blood samples for IL-6, TGF-β1, and PDGF were obtained. Serum GH, IGF1, HbA1c, pituitary hormones and MRI sella were performed in patients with acromegaly. There was no significant difference in periodontal status of patients with acromegaly and healthy controls. However, a significant increase in serum IL-6 (p = 0.019) and TGF-β1 (p = 0.025) levels in patients with acromegaly was observed and all patients had concurrent hypogonadism. Nevertheless, the patients with acromegaly having diabetes had modestly higher CAL and PD and serum IL-6 levels (p = 0.051), but it could not exert adverse effects on periodontal health in presence of GH/IGF1 excess. GH/IGF1 excess did not exert a protective effect on periodontal status in acromegaly, possibly due to concurrent hypogonadism and opposing cytokines; however, it could mask the ill-effects of diabetes on periodontal health. |
format | Online Article Text |
id | pubmed-7645583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76455832020-11-06 Impact of concurrent diabetes on periodontal health in patients with acromegaly Jain, Akanksha Gupta, Shipra Bhansali, Anil Gupta, Mili Jain, Ashish Bhaskar, Nandini Kaur, Rose Kanwaljeet Sci Rep Article Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytokines status in treatment-naive active acromegaly patients with and without diabetes. Eleven patients, each of acromegaly with and without diabetes and 20 healthy controls were enrolled. Periodontal parameters were assessed. GCF and blood samples for IL-6, TGF-β1, and PDGF were obtained. Serum GH, IGF1, HbA1c, pituitary hormones and MRI sella were performed in patients with acromegaly. There was no significant difference in periodontal status of patients with acromegaly and healthy controls. However, a significant increase in serum IL-6 (p = 0.019) and TGF-β1 (p = 0.025) levels in patients with acromegaly was observed and all patients had concurrent hypogonadism. Nevertheless, the patients with acromegaly having diabetes had modestly higher CAL and PD and serum IL-6 levels (p = 0.051), but it could not exert adverse effects on periodontal health in presence of GH/IGF1 excess. GH/IGF1 excess did not exert a protective effect on periodontal status in acromegaly, possibly due to concurrent hypogonadism and opposing cytokines; however, it could mask the ill-effects of diabetes on periodontal health. Nature Publishing Group UK 2020-11-05 /pmc/articles/PMC7645583/ /pubmed/33154456 http://dx.doi.org/10.1038/s41598-020-76067-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Jain, Akanksha Gupta, Shipra Bhansali, Anil Gupta, Mili Jain, Ashish Bhaskar, Nandini Kaur, Rose Kanwaljeet Impact of concurrent diabetes on periodontal health in patients with acromegaly |
title | Impact of concurrent diabetes on periodontal health in patients with acromegaly |
title_full | Impact of concurrent diabetes on periodontal health in patients with acromegaly |
title_fullStr | Impact of concurrent diabetes on periodontal health in patients with acromegaly |
title_full_unstemmed | Impact of concurrent diabetes on periodontal health in patients with acromegaly |
title_short | Impact of concurrent diabetes on periodontal health in patients with acromegaly |
title_sort | impact of concurrent diabetes on periodontal health in patients with acromegaly |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645583/ https://www.ncbi.nlm.nih.gov/pubmed/33154456 http://dx.doi.org/10.1038/s41598-020-76067-5 |
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