Cargando…

Impact of concurrent diabetes on periodontal health in patients with acromegaly

Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytok...

Descripción completa

Detalles Bibliográficos
Autores principales: Jain, Akanksha, Gupta, Shipra, Bhansali, Anil, Gupta, Mili, Jain, Ashish, Bhaskar, Nandini, Kaur, Rose Kanwaljeet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645583/
https://www.ncbi.nlm.nih.gov/pubmed/33154456
http://dx.doi.org/10.1038/s41598-020-76067-5
_version_ 1783606658538143744
author Jain, Akanksha
Gupta, Shipra
Bhansali, Anil
Gupta, Mili
Jain, Ashish
Bhaskar, Nandini
Kaur, Rose Kanwaljeet
author_facet Jain, Akanksha
Gupta, Shipra
Bhansali, Anil
Gupta, Mili
Jain, Ashish
Bhaskar, Nandini
Kaur, Rose Kanwaljeet
author_sort Jain, Akanksha
collection PubMed
description Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytokines status in treatment-naive active acromegaly patients with and without diabetes. Eleven patients, each of acromegaly with and without diabetes and 20 healthy controls were enrolled. Periodontal parameters were assessed. GCF and blood samples for IL-6, TGF-β1, and PDGF were obtained. Serum GH, IGF1, HbA1c, pituitary hormones and MRI sella were performed in patients with acromegaly. There was no significant difference in periodontal status of patients with acromegaly and healthy controls. However, a significant increase in serum IL-6 (p = 0.019) and TGF-β1 (p = 0.025) levels in patients with acromegaly was observed and all patients had concurrent hypogonadism. Nevertheless, the patients with acromegaly having diabetes had modestly higher CAL and PD and serum IL-6 levels (p = 0.051), but it could not exert adverse effects on periodontal health in presence of GH/IGF1 excess. GH/IGF1 excess did not exert a protective effect on periodontal status in acromegaly, possibly due to concurrent hypogonadism and opposing cytokines; however, it could mask the ill-effects of diabetes on periodontal health.
format Online
Article
Text
id pubmed-7645583
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-76455832020-11-06 Impact of concurrent diabetes on periodontal health in patients with acromegaly Jain, Akanksha Gupta, Shipra Bhansali, Anil Gupta, Mili Jain, Ashish Bhaskar, Nandini Kaur, Rose Kanwaljeet Sci Rep Article Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytokines status in treatment-naive active acromegaly patients with and without diabetes. Eleven patients, each of acromegaly with and without diabetes and 20 healthy controls were enrolled. Periodontal parameters were assessed. GCF and blood samples for IL-6, TGF-β1, and PDGF were obtained. Serum GH, IGF1, HbA1c, pituitary hormones and MRI sella were performed in patients with acromegaly. There was no significant difference in periodontal status of patients with acromegaly and healthy controls. However, a significant increase in serum IL-6 (p = 0.019) and TGF-β1 (p = 0.025) levels in patients with acromegaly was observed and all patients had concurrent hypogonadism. Nevertheless, the patients with acromegaly having diabetes had modestly higher CAL and PD and serum IL-6 levels (p = 0.051), but it could not exert adverse effects on periodontal health in presence of GH/IGF1 excess. GH/IGF1 excess did not exert a protective effect on periodontal status in acromegaly, possibly due to concurrent hypogonadism and opposing cytokines; however, it could mask the ill-effects of diabetes on periodontal health. Nature Publishing Group UK 2020-11-05 /pmc/articles/PMC7645583/ /pubmed/33154456 http://dx.doi.org/10.1038/s41598-020-76067-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jain, Akanksha
Gupta, Shipra
Bhansali, Anil
Gupta, Mili
Jain, Ashish
Bhaskar, Nandini
Kaur, Rose Kanwaljeet
Impact of concurrent diabetes on periodontal health in patients with acromegaly
title Impact of concurrent diabetes on periodontal health in patients with acromegaly
title_full Impact of concurrent diabetes on periodontal health in patients with acromegaly
title_fullStr Impact of concurrent diabetes on periodontal health in patients with acromegaly
title_full_unstemmed Impact of concurrent diabetes on periodontal health in patients with acromegaly
title_short Impact of concurrent diabetes on periodontal health in patients with acromegaly
title_sort impact of concurrent diabetes on periodontal health in patients with acromegaly
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645583/
https://www.ncbi.nlm.nih.gov/pubmed/33154456
http://dx.doi.org/10.1038/s41598-020-76067-5
work_keys_str_mv AT jainakanksha impactofconcurrentdiabetesonperiodontalhealthinpatientswithacromegaly
AT guptashipra impactofconcurrentdiabetesonperiodontalhealthinpatientswithacromegaly
AT bhansalianil impactofconcurrentdiabetesonperiodontalhealthinpatientswithacromegaly
AT guptamili impactofconcurrentdiabetesonperiodontalhealthinpatientswithacromegaly
AT jainashish impactofconcurrentdiabetesonperiodontalhealthinpatientswithacromegaly
AT bhaskarnandini impactofconcurrentdiabetesonperiodontalhealthinpatientswithacromegaly
AT kaurrosekanwaljeet impactofconcurrentdiabetesonperiodontalhealthinpatientswithacromegaly