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Engineering microrobots for targeted cancer therapies from a medical perspective

Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of therapeutics remains challenging. Engineering micr...

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Autores principales: Schmidt, Christine K., Medina-Sánchez, Mariana, Edmondson, Richard J., Schmidt, Oliver G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645678/
https://www.ncbi.nlm.nih.gov/pubmed/33154372
http://dx.doi.org/10.1038/s41467-020-19322-7
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author Schmidt, Christine K.
Medina-Sánchez, Mariana
Edmondson, Richard J.
Schmidt, Oliver G.
author_facet Schmidt, Christine K.
Medina-Sánchez, Mariana
Edmondson, Richard J.
Schmidt, Oliver G.
author_sort Schmidt, Christine K.
collection PubMed
description Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of therapeutics remains challenging. Engineering microrobots is increasingly receiving attention in this regard. Their functionalities, particularly their motility, allow microrobots to penetrate tissues and reach cancers more efficiently. Here, we highlight how different microrobots, ranging from tailor-made motile bacteria and tiny bubble-propelled microengines to hybrid spermbots, can be engineered to integrate sophisticated features optimised for precision-targeting of a wide range of cancers. Towards this, we highlight the importance of integrating clinicians, the public and cancer patients early on in the development of these novel technologies.
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spelling pubmed-76456782020-11-10 Engineering microrobots for targeted cancer therapies from a medical perspective Schmidt, Christine K. Medina-Sánchez, Mariana Edmondson, Richard J. Schmidt, Oliver G. Nat Commun Review Article Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of therapeutics remains challenging. Engineering microrobots is increasingly receiving attention in this regard. Their functionalities, particularly their motility, allow microrobots to penetrate tissues and reach cancers more efficiently. Here, we highlight how different microrobots, ranging from tailor-made motile bacteria and tiny bubble-propelled microengines to hybrid spermbots, can be engineered to integrate sophisticated features optimised for precision-targeting of a wide range of cancers. Towards this, we highlight the importance of integrating clinicians, the public and cancer patients early on in the development of these novel technologies. Nature Publishing Group UK 2020-11-05 /pmc/articles/PMC7645678/ /pubmed/33154372 http://dx.doi.org/10.1038/s41467-020-19322-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Schmidt, Christine K.
Medina-Sánchez, Mariana
Edmondson, Richard J.
Schmidt, Oliver G.
Engineering microrobots for targeted cancer therapies from a medical perspective
title Engineering microrobots for targeted cancer therapies from a medical perspective
title_full Engineering microrobots for targeted cancer therapies from a medical perspective
title_fullStr Engineering microrobots for targeted cancer therapies from a medical perspective
title_full_unstemmed Engineering microrobots for targeted cancer therapies from a medical perspective
title_short Engineering microrobots for targeted cancer therapies from a medical perspective
title_sort engineering microrobots for targeted cancer therapies from a medical perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645678/
https://www.ncbi.nlm.nih.gov/pubmed/33154372
http://dx.doi.org/10.1038/s41467-020-19322-7
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