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HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study
The atherogenic process begins already in childhood and progresses to symptomatic condition with age. We investigated the association of cholesterol efflux capacity (CEC) and vascular markers of subclinical atherosclerosis in healthy, young adults. CEC was determined in 2282 participants of the Youn...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645719/ https://www.ncbi.nlm.nih.gov/pubmed/33154477 http://dx.doi.org/10.1038/s41598-020-76146-7 |
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author | Hunjadi, Monika Lamina, Claudia Kahler, Patrick Bernscherer, Tamara Viikari, Jorma Lehtimäki, Terho Kähönen, Mika Hurme, Mikko Juonala, Markus Taittonen, Leena Laitinen, Tomi Jokinen, Eero Tossavainen, Päivi Hutri-Kähönen, Nina Raitakari, Olli Ritsch, Andreas |
author_facet | Hunjadi, Monika Lamina, Claudia Kahler, Patrick Bernscherer, Tamara Viikari, Jorma Lehtimäki, Terho Kähönen, Mika Hurme, Mikko Juonala, Markus Taittonen, Leena Laitinen, Tomi Jokinen, Eero Tossavainen, Päivi Hutri-Kähönen, Nina Raitakari, Olli Ritsch, Andreas |
author_sort | Hunjadi, Monika |
collection | PubMed |
description | The atherogenic process begins already in childhood and progresses to symptomatic condition with age. We investigated the association of cholesterol efflux capacity (CEC) and vascular markers of subclinical atherosclerosis in healthy, young adults. CEC was determined in 2282 participants of the Young Finns study using cAMP treated (3)H-cholesterol-labeled J774 cells. The CEC was correlated to baseline and 6-year follow-up data of cardiovascular risk factors and ultrasound measurements of arterial structure and function. CEC was higher in women, correlated with total cholesterol, HDL-C, and apolipoprotein A-I, but not with LDL-C or apolipoprotein B. Compared to the lowest CEC quartile, the highest CEC quartile was significantly associated with high CRP levels and inversely associated with adiponectin. At baseline, high CEC was associated with decreased flow-mediated dilation (FMD) and carotid artery distensibility, as well as an increased Young's modulus of elasticity, indicating adverse changes in arterial structure, and function. The association reversed with follow-up FMD data, indicating the interaction of preclinical parameters over time. A higher CEC was directly associated with a lower risk of subclinical atherosclerosis at follow-up. In young and healthy subjects, CEC was associated with important lipid risk parameters at baseline, as in older patients and CAD patients, but inversely with early risk markers for subclinical atherosclerosis. |
format | Online Article Text |
id | pubmed-7645719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76457192020-11-06 HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study Hunjadi, Monika Lamina, Claudia Kahler, Patrick Bernscherer, Tamara Viikari, Jorma Lehtimäki, Terho Kähönen, Mika Hurme, Mikko Juonala, Markus Taittonen, Leena Laitinen, Tomi Jokinen, Eero Tossavainen, Päivi Hutri-Kähönen, Nina Raitakari, Olli Ritsch, Andreas Sci Rep Article The atherogenic process begins already in childhood and progresses to symptomatic condition with age. We investigated the association of cholesterol efflux capacity (CEC) and vascular markers of subclinical atherosclerosis in healthy, young adults. CEC was determined in 2282 participants of the Young Finns study using cAMP treated (3)H-cholesterol-labeled J774 cells. The CEC was correlated to baseline and 6-year follow-up data of cardiovascular risk factors and ultrasound measurements of arterial structure and function. CEC was higher in women, correlated with total cholesterol, HDL-C, and apolipoprotein A-I, but not with LDL-C or apolipoprotein B. Compared to the lowest CEC quartile, the highest CEC quartile was significantly associated with high CRP levels and inversely associated with adiponectin. At baseline, high CEC was associated with decreased flow-mediated dilation (FMD) and carotid artery distensibility, as well as an increased Young's modulus of elasticity, indicating adverse changes in arterial structure, and function. The association reversed with follow-up FMD data, indicating the interaction of preclinical parameters over time. A higher CEC was directly associated with a lower risk of subclinical atherosclerosis at follow-up. In young and healthy subjects, CEC was associated with important lipid risk parameters at baseline, as in older patients and CAD patients, but inversely with early risk markers for subclinical atherosclerosis. Nature Publishing Group UK 2020-11-05 /pmc/articles/PMC7645719/ /pubmed/33154477 http://dx.doi.org/10.1038/s41598-020-76146-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hunjadi, Monika Lamina, Claudia Kahler, Patrick Bernscherer, Tamara Viikari, Jorma Lehtimäki, Terho Kähönen, Mika Hurme, Mikko Juonala, Markus Taittonen, Leena Laitinen, Tomi Jokinen, Eero Tossavainen, Päivi Hutri-Kähönen, Nina Raitakari, Olli Ritsch, Andreas HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study |
title | HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study |
title_full | HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study |
title_fullStr | HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study |
title_full_unstemmed | HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study |
title_short | HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study |
title_sort | hdl cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: the cardiovascular risk in young finns study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645719/ https://www.ncbi.nlm.nih.gov/pubmed/33154477 http://dx.doi.org/10.1038/s41598-020-76146-7 |
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