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Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations

Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in the tricarboxylic acid (TCA) cycle. Studies have reve...

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Detalles Bibliográficos
Autores principales:	Wang, Yuan, Deng, Peng, Liu, Yuting, Wu, Yunshu, Chen, Yaqian, Guo, Yuchen, Zhang, Shiwen, Zheng, Xiaofei, Zhou, Liyan, Liu, Weiqing, Li, Qiwen, Lin, Weimin, Qi, Xingying, Ou, Guomin, Wang, Cunyu, Yuan, Quan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645772/ https://www.ncbi.nlm.nih.gov/pubmed/33154378 http://dx.doi.org/10.1038/s41467-020-19360-1

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