Cargando…

Histone deacetylase inhibitor MPT0B291 suppresses Glioma Growth in vitro and in vivo partially through acetylation of p53

Background: Histone deacetylase (HDAC) inhibitors have emerged as a new class of anti-tumor agents for various types of tumors, including glioblastoma. Methods and results: We found that a novel HDAC inhibitor, MPT0B291, significantly reduced the cell viability and increased cell death of human and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buyandelger, Batsaikhan, Bar, Eli E, Hung, Kuo-Sheng, Chen, Ruei-Ming, Chiang, Yung-Hsiao, Liou, Jing-Ping, Huang, Huei-Mei, Wang, Jia-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645997/ https://www.ncbi.nlm.nih.gov/pubmed/33162824 http://dx.doi.org/10.7150/ijbs.45505

Ejemplares similares

Optimization and Development of Selective Histone Deacetylase Inhibitor (MPT0B291)-Loaded Albumin Nanoparticles for Anticancer Therapy
por: Putri, Athika Darumas, et al.
Publicado: (2021)

Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009
por: Hsieh, I-N, et al.
Publicado: (2014)

Acetylation and Histone Deacetylase Inhibitors in Cancer
por: Kortenhorst, Madeleine S. Q., et al.
Publicado: (2006)

A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model
por: Yeh, Lu-Yang, et al.
Publicado: (2022)

Histone acetylation and the role of histone deacetylases in normal cyclic endometrium
por: Gujral, Palak, et al.
Publicado: (2020)

Myelodysplastic Syndrome and Histone Deacetylase Inhibitors: “To Be or Not to Be Acetylated”?
por: Stintzing, Sebastian, et al.
Publicado: (2011)

Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo
por: Huang, Han-Lin, et al.
Publicado: (2012)

Histone deacetylase 3 indirectly modulates tubulin acetylation
por: Bacon, Travis, et al.
Publicado: (2015)

Correction: Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo
por: Huang, Han-Li, et al.
Publicado: (2012)

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo
por: Huang, Han-Li, et al.
Publicado: (2014)

Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8
por: Yan, Wensheng, et al.
Publicado: (2012)

Histone deacetylases control lysine acetylation of ribosomal proteins in rice
por: Xu, Qiutao, et al.
Publicado: (2021)

Dysferlin Interacts with Histone Deacetylase 6 and Increases alpha-Tubulin Acetylation
por: Di Fulvio, Sabrina, et al.
Publicado: (2011)

Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men
por: Kim, Jee Hyun, et al.
Publicado: (2014)

Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo
por: Kelly, R. D. W., et al.
Publicado: (2018)

Methylation-directed acetylation of histone H3 regulates developmental sensitivity to histone deacetylase inhibition
por: Huang, Li-Yao, et al.
Publicado: (2021)

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma
por: Chen, Mei-Chuan, et al.
Publicado: (2015)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

Retraction: Dysferlin Interacts with Histone Deacetylase 6 and Increases alpha-Tubulin Acetylation
Publicado: (2018)

Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors
por: Shen, Fangzhou, et al.
Publicado: (2019)

Histone‐deacetylase 8 drives the immune response and the growth of glioma
por: Mormino, Alessandro, et al.
Publicado: (2021)

Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway
por: Lan, Xintian, et al.
Publicado: (2023)

Application of Electric Cell-Substrate Impedance Sensing to Investigate the Cytotoxic Effects of Andrographolide on U-87 MG Glioblastoma Cell Migration and Apoptosis
por: Chiu, Sheng-Po, et al.
Publicado: (2019)

Histone Deacetylase 1 Plays an Acetylation-Independent Role in Influenza A Virus Replication
por: Chen, Lin, et al.
Publicado: (2017)

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model
por: Fan, Sheng-Jun, et al.
Publicado: (2018)

Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation
por: Bao, Lianmin, et al.
Publicado: (2016)

Comprehensive Analysis of the Differential Expression and Prognostic Value of Histone Deacetylases in Glioma
por: Li, Jinwei, et al.
Publicado: (2022)

Effects of caffeine on cell viability and activity of histone deacetylase 1 and histone acetyltransferase in glioma cells
por: Chen, Jin-Cherng, et al.
Publicado: (2016)

p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors
por: Sonnemann, J, et al.
Publicado: (2014)

Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In Vivo
por: Lee, Yuri, et al.
Publicado: (2021)

Ginsenoside Rg3 Inhibits Melanoma Cell Proliferation through Down-Regulation of Histone Deacetylase 3 (HDAC3) and Increase of p53 Acetylation
por: Shan, Xiu, et al.
Publicado: (2014)

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
por: Sun, Xin, et al.
Publicado: (2022)

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates
por: Yao, Ya-Li, et al.
Publicado: (2011)

Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53
por: Mrakovcic, Maria, et al.
Publicado: (2017)

Comprehensive analysis of histone deacetylases genes in the prognosis and immune infiltration of glioma patients
por: Shen, Lin, et al.
Publicado: (2022)

Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma
por: Marquard, L, et al.
Publicado: (2008)

Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni
por: Anderson, Letícia, et al.
Publicado: (2017)

Jasmonates and Histone deacetylase 6 activate Arabidopsis genome-wide histone acetylation and methylation during the early acute stress response
por: Vincent, Stacey A., et al.
Publicado: (2022)

A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation
por: De, Umasankar, et al.
Publicado: (2018)

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers
por: Sanaei, Masumeh, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1362gm78oer4b0oot44ha5vcij