Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model

BACKGROUND: Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss. OBJECTIVE: This study is focused on the role of Hv1 in regulating demyelination and microglial activation through reac...

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Detalles Bibliográficos
Autores principales: Chen, Man, Yang, Lin-Lin, Hu, Zi-Wei, Qin, Chuan, Zhou, Luo-Qi, Duan, Ya-ling, Bosco, Dale B., Wu, Long-Jun, Zhan, Ke-Bin, Xu, Sha-Bei, Tian, Dai-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646080/
https://www.ncbi.nlm.nih.gov/pubmed/33158440
http://dx.doi.org/10.1186/s12974-020-02020-y

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